Dudda Marcel, Godau Peter, Al-Benna Sammy, Schildhauer Thomas A, Gothner Martin
Department of General and Trauma Surgery University Hospital Bergmannsheil GmbH, Ruhr- University Bochum, Bürkle de-la-Camp Platz 1 44789 Bochum, Germany.
Recent Pat Inflamm Allergy Drug Discov. 2013 May;7(2):176-82. doi: 10.2174/1872213x11307020009.
Orthopaedic joint implants and osteosynthetic materials are progressively being employed more often. Complications mainly include physical-mechanical problems and infections. Uncommonly, allergic reactions to an alloy metal or a bone cement component have been implicated. Less attention has been paid to the components of bone cement, such as acrylate, catalysers (e.g. peroxide), additive polymers or stabilisers. An important bone cement component is benzoylperoxide (BPO), an initiator of the process enhancement of the bone cement. Vitiligo is an acquired, progressive depigmenting disorder that can induce autoimmune diseases. The occurrence of vitiligo in combination with an infection or allergy is not well described, and this manuscript highlights the possibility of an occurrence of a vitiligo whenever the immunesystem is activated and T-cell activation is observed. The aim of this article was to analyze the diagnosis and management of vitiligo and allergic complications from orthopaedic joint implants due to benzoyl-peroxide and relevant patents.
骨科关节植入物和骨合成材料的使用越来越频繁。并发症主要包括物理机械问题和感染。罕见的是，有人认为对合金金属或骨水泥成分会发生过敏反应。人们对骨水泥的成分，如丙烯酸酯、催化剂（如过氧化物）、添加剂聚合物或稳定剂的关注较少。一种重要的骨水泥成分是过氧化苯甲酰（BPO），它是增强骨水泥过程的引发剂。白癜风是一种获得性、进行性色素脱失性疾病，可诱发自身免疫性疾病。白癜风与感染或过敏同时发生的情况描述不多，本文强调了每当免疫系统被激活且观察到T细胞活化时发生白癜风的可能性。本文的目的是分析白癜风的诊断和管理以及由过氧化苯甲酰引起的骨科关节植入物过敏并发症及相关专利。
