Inzelberg R, Shapira T, Korczyn A D
Department of Neurology, Tel Aviv Medical Center, Israel.
Clin Neuropharmacol. 1990 Jun;13(3):241-7. doi: 10.1097/00002826-199006000-00007.
The effect of intravenous atropine (1 mg) or saline on mnemonic function was tested in patients with various forms of dementia and age-matched controls. Examinees consisted of 12 subjects having Alzheimer's disease (AD), multi-infarct dementia (MID), Parkinson's disease without dementia or with dementia, and normal aged controls. Wechsler's adult memory scale was used. Orientation, visual reproduction, and associative learning were not affected by this small dose of atropine in any of the subgroups. On the other hand, digit span and logical memory were selectively impaired by atropine in AD. The more sensitive parameters were the improvement on retesting (reflecting learning abilities). This study suggests that cholinergic dysfunction is responsible for abnormalities in logical memory and digit span in AD or the dementia of Parkinson's disease but not in MID.
在患有各种形式痴呆症的患者以及年龄匹配的对照组中，测试了静脉注射阿托品（1毫克）或生理盐水对记忆功能的影响。受试者包括12名患有阿尔茨海默病（AD）、多发性梗死性痴呆（MID）、无痴呆或伴有痴呆的帕金森病患者以及正常老年对照组。使用了韦氏成人记忆量表。在任何亚组中，这种小剂量的阿托品均未影响定向、视觉再现和联想学习。另一方面，在AD患者中，阿托品选择性地损害了数字广度和逻辑记忆。更敏感的参数是复测时的改善情况（反映学习能力）。这项研究表明，胆碱能功能障碍是AD或帕金森病痴呆患者逻辑记忆和数字广度异常的原因，但不是MID患者异常的原因。
