• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

B淋巴细胞中的转录停滞：抗体多样化和基因组完整性维持的一种机制。

Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity.

作者信息

Sun Jianbo, Rothschild Gerson, Pefanis Evangelos, Basu Uttiya

机构信息

Department of Microbiology and Immunology; College of Physicians and Surgeons; Columbia University; New York, NY USA.

出版信息

Transcription. 2013 May-Jun;4(3):127-35. doi: 10.4161/trns.24556. Epub 2013 Apr 12.

DOI:10.4161/trns.24556
PMID:23584095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4042586/
Abstract

B cells utilize three DNA alteration strategies-V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)-to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of these three events, the single-strand DNA cytidine deaminase, Activation Induced cytidine Deaminase (AID), is responsible for SHM and CSR. Recent advances, discussed in this review article, point toward various components of RNA polymerase II "stalling" machinery as regulators of AID activity during antibody diversification and maintenance of B cell genome integrity.

摘要

B细胞利用三种DNA改变策略——V(D)J重组、体细胞超突变(SHM)和类别转换重组(CSR)——对其基因组进行体细胞突变，从而表达出大量针对其在循环中遇到的无数抗原量身定制的抗体。在这三种事件中，单链DNA胞苷脱氨酶，即激活诱导胞苷脱氨酶(AID)，负责SHM和CSR。本文综述中讨论的最新进展表明，RNA聚合酶II“停滞”机制的各种成分是抗体多样化和B细胞基因组完整性维持过程中AID活性的调节因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/e1357305ce33/tran-4-127-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/ce6ad57c9243/tran-4-127-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/b3556a1bb13f/tran-4-127-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/2552aedc8131/tran-4-127-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/e1357305ce33/tran-4-127-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/ce6ad57c9243/tran-4-127-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/b3556a1bb13f/tran-4-127-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/2552aedc8131/tran-4-127-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0e/4042586/e1357305ce33/tran-4-127-g4.jpg

相似文献

1
Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity.B淋巴细胞中的转录停滞：抗体多样化和基因组完整性维持的一种机制。
Transcription. 2013 May-Jun;4(3):127-35. doi: 10.4161/trns.24556. Epub 2013 Apr 12.
2
Regulation of AID, the B-cell genome mutator.调控 AID，B 细胞基因组的突变酶。
Genes Dev. 2013 Jan 1;27(1):1-17. doi: 10.1101/gad.200014.112.
3
A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.体细胞高频突变过程中激活诱导脱氨酶的单链DNA底物来源。
Nat Commun. 2014 Jun 13;5:4137. doi: 10.1038/ncomms5137.
4
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.激活诱导的胞嘧啶脱氨酶（AID）介导的免疫球蛋白Sμ区域高突变：AID参与类别转换重组和体细胞高频突变共同步骤的意义
J Exp Med. 2002 Feb 18;195(4):529-34. doi: 10.1084/jem.20012144.
5
RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase.hnRNP K 的 RNA 结合基序对于激活诱导的胞苷脱氨酶诱导抗体多样化是至关重要的。
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11624-11635. doi: 10.1073/pnas.1921115117. Epub 2020 May 8.
6
Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation.活化诱导的胞苷脱氨酶：在类别转换重排和体细胞高频突变中的双重作用。
Eur J Immunol. 2003 Aug;33(8):2069-73. doi: 10.1002/eji.200324133.
7
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.鉴定激活诱导胞苷脱氨酶的DNA切割和重组特异性hnRNP辅因子。
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5791-6. doi: 10.1073/pnas.1506167112. Epub 2015 Apr 20.
8
AID targeting in antibody diversity.抗体多样性中的 AID 靶向。
Adv Immunol. 2011;110:1-26. doi: 10.1016/B978-0-12-387663-8.00005-3.
9
RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations.RNA外泌体与AID介导的基因组改变中的非编码RNA偶联机制
J Mol Biol. 2017 Oct 27;429(21):3230-3241. doi: 10.1016/j.jmb.2016.12.021. Epub 2017 Jan 7.
10
AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4.狼疮易感 MRL/Fas(lpr/lpr) 小鼠中的 AID 失调增加了类别转换 DNA 重组，并促进了染色体间 c-Myc/IgH 基因座易位：由 HoxC4 调节。
Autoimmunity. 2011 Dec;44(8):585-98. doi: 10.3109/08916934.2011.577128. Epub 2011 May 18.

引用本文的文献

1
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination.高效的体细胞超突变和类别转换重组需要转录延伸因子ELOF1。
Mol Cell. 2025 Apr 3;85(7):1296-1310.e7. doi: 10.1016/j.molcel.2025.02.007. Epub 2025 Mar 5.
2
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination.高效的体细胞高频突变和类别转换重组需要转录延伸因子ELOF1。
bioRxiv. 2024 Sep 26:2024.09.24.614732. doi: 10.1101/2024.09.24.614732.
3
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression.

本文引用的文献

1
RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle.在类别转换重组过程中，RPA 积累代表了细胞周期 S-G2/M 期的 5'-3' DNA 末端切除。
Cell Rep. 2013 Jan 31;3(1):138-47. doi: 10.1016/j.celrep.2012.12.006. Epub 2013 Jan 3.
2
Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase.基于溶解度的遗传筛选鉴定出 RING 指蛋白 126 是激活诱导胞嘧啶脱氨酶的 E3 连接酶。
Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1029-34. doi: 10.1073/pnas.1214538110. Epub 2012 Dec 31.
3
非编码突变导致超级增强子重新靶向，导致 B 细胞淋巴瘤进展过程中蛋白质合成失调。
Nat Genet. 2023 Dec;55(12):2160-2174. doi: 10.1038/s41588-023-01561-1. Epub 2023 Dec 4.
4
How Estrogen, Testosterone, and Sex Differences Influence Serum Immunoglobulin Isotype Patterns in Mice and Humans.雌激素、睾酮和性别差异如何影响小鼠和人类的血清免疫球蛋白同种型模式。
Viruses. 2023 Feb 9;15(2):482. doi: 10.3390/v15020482.
5
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation.HMCES 特异性保护免疫球蛋白基因免受体细胞高频突变中的缺失。
Genes Dev. 2022 Apr 1;36(7-8):433-450. doi: 10.1101/gad.349438.122. Epub 2022 Apr 21.
6
The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions.HIRA 依赖性 H3.3 沉积及其修饰在免疫球蛋白可变区体细胞超突变中的作用。
Proc Natl Acad Sci U S A. 2021 Dec 14;118(50). doi: 10.1073/pnas.2114743118.
7
A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes.基于贝叶斯模型的染色质中可及单链 DNA 与免疫球蛋白基因体细胞高频突变关系的计算分析。
PLoS Comput Biol. 2021 Sep 7;17(9):e1009323. doi: 10.1371/journal.pcbi.1009323. eCollection 2021 Sep.
8
Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes.Dot1L 和 H3K79 甲基化在调节免疫球蛋白基因体细胞超突变中的作用。
Proc Natl Acad Sci U S A. 2021 Jul 20;118(29). doi: 10.1073/pnas.2104013118.
9
Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting.转录因子在 Ig 增强子上的结合与体细胞高频突变的靶向有关。
Eur J Immunol. 2020 Mar;50(3):380-395. doi: 10.1002/eji.201948357. Epub 2019 Dec 19.
10
Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers.复杂的性别偏倚抗体反应：雌激素受体结合位于免疫球蛋白重链基因增强子内的雌激素反应元件。
Int Immunol. 2019 Mar 5;31(3):141-156. doi: 10.1093/intimm/dxy074.
Defining the status of RNA polymerase at promoters.
定义启动子处 RNA 聚合酶的状态。
Cell Rep. 2012 Oct 25;2(4):1025-35. doi: 10.1016/j.celrep.2012.08.034. Epub 2012 Oct 10.
4
DNA secondary structures: stability and function of G-quadruplex structures.DNA 二级结构：G-四链体结构的稳定性和功能。
Nat Rev Genet. 2012 Nov;13(11):770-80. doi: 10.1038/nrg3296. Epub 2012 Oct 3.
5
The RNA polymerase II CTD coordinates transcription and RNA processing.RNA 聚合酶 II CTD 协调转录和 RNA 加工。
Genes Dev. 2012 Oct 1;26(19):2119-37. doi: 10.1101/gad.200303.112.
6
Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase.染色体易位、B 细胞淋巴瘤和激活诱导的胞嘧啶脱氨酶。
Annu Rev Pathol. 2013 Jan 24;8:79-103. doi: 10.1146/annurev-pathol-020712-164004. Epub 2012 Sep 4.
7
Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications.调节 AID 依赖性 DNA 脱氨酶的组合机制：相互作用的蛋白质和翻译后修饰。
Semin Immunol. 2012 Aug;24(4):264-72. doi: 10.1016/j.smim.2012.05.006. Epub 2012 Jul 6.
8
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.免疫球蛋白类别转换 DNA 重组：诱导、靶向及其他。
Nat Rev Immunol. 2012 Jun 25;12(7):517-31. doi: 10.1038/nri3216.
9
A movie of RNA polymerase II transcription.RNA 聚合酶 II 转录的电影。
Cell. 2012 Jun 22;149(7):1431-7. doi: 10.1016/j.cell.2012.06.006.
10
Activation induced deaminase: how much and where?激活诱导脱氨酶：多少和哪里？
Semin Immunol. 2012 Aug;24(4):246-54. doi: 10.1016/j.smim.2012.05.001. Epub 2012 Jun 9.