Kengeri S S, Maras A H, Suckow C L, Chiang E C, Waters D J
Center for Exceptional Longevity Studies, Gerald P. Murphy Cancer Foundation, West Lafayette, IN, USA.
Age (Dordr). 2013 Dec;35(6):2503-13. doi: 10.1007/s11357-013-9529-8. Epub 2013 Apr 13.
To better understand the potential trade-off between female reproductive investment and longevity in an emerging model of human healthspan, we studied pet dogs to determine whether intensity of reproduction (total number of offspring) encumbered the likelihood of exceptional longevity. This hypothesis was tested by collecting and analyzing lifetime medical histories, including complete reproductive histories, for a cohort of canine "centenarians"--exceptionally long-lived Rottweiler dogs that lived more than 30% longer than the breed's average life expectancy. Reproductive intensity (number of litters, total number of pups) and tempo of reproductive effort (age at first reproduction, mean interbirth interval, age at last reproduction) in 78 exceptionally long-lived female Rottweilers (>13 years old) were compared to a cohort of 97 female Rottweilers that had usual longevity (age at death 8.0-10.75 years). We found no evidence that a mother's physiological investment in offspring was associated with disadvantaged longevity. Instead, similar to some studies in women, our data showed an inverted U-shaped trend, suggesting that moderate investment in reproduction may promote longevity. Late reproductive success, a much-studied surrogate of maternal fitness in women, was not a strong predictor of longevity in this canine cohort. Instead, independent of reproductive investment, the duration of lifetime ovary exposure was significantly associated with highly successful aging. Our results from exceptionally long-lived pet dogs provide rationale for further investigative efforts to understand the ovary-sensitive biological factors that promote healthy longevity in women and pet dogs.
为了在一种新兴的人类健康寿命模型中更好地理解雌性生殖投资与寿命之间可能存在的权衡关系，我们对宠物狗进行了研究，以确定繁殖强度（后代总数）是否会影响超长寿命的可能性。我们通过收集和分析一组犬类“百岁寿星”（即寿命极长的罗威纳犬，其寿命比该品种的平均预期寿命长30%以上）的终生医疗史（包括完整的生殖史）来验证这一假设。将78只超长寿命的雌性罗威纳犬（>13岁）的繁殖强度（产窝数、幼犬总数）和繁殖努力节奏（首次繁殖年龄、平均产仔间隔、末次繁殖年龄）与97只具有正常寿命（死亡年龄为8.0 - 10.75岁）的雌性罗威纳犬进行了比较。我们没有发现证据表明母亲对后代的生理投资与寿命缩短有关。相反，与一些关于女性的研究类似，我们的数据显示出一种倒U形趋势，表明适度的生殖投资可能会促进长寿。晚期生殖成功是女性中备受研究的母体健康指标，但在这个犬类群体中并不是长寿的有力预测指标。相反，独立于生殖投资之外，终生卵巢暴露的持续时间与高度成功的衰老显著相关。我们对超长寿命宠物狗的研究结果为进一步开展调查研究提供了理论依据，以了解促进女性和宠物狗健康长寿的卵巢敏感生物因素。
