Kent Michael S, Burton Jenna H, Dank Gillian, Bannasch Danika L, Rebhun Robert B
Department of Surgical and Radiological Sciences, University of California Davis School of Veterinary Medicine, Davis, CA, United States of America.
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
PLoS One. 2018 Feb 6;13(2):e0192578. doi: 10.1371/journal.pone.0192578. eCollection 2018.
Golden retriever dogs have been reported to have an increased prevalence of cancer compared to other breeds. There is also controversy over the effect spay or neuter status might have on longevity and the risk for developing cancer. The electronic medical records system at an academic center was searched for all dogs who had a necropsy exam from 1989-2016. 9,677 canine necropsy examinations were completed of which 655 were golden retrievers. Age was known for 652 with a median age of death 9.15 years. 424 of the 652 (65.0%) were determined to have died because of cancer. The median age for dying of a cause other than cancer was 6.93 years while those dying of cancer had a median age of 9.83 years (p<0.0001). There was no significant difference in the proportion of intact males and castrated males dying of cancer (p = 0.43) but a greater proportion of spayed females died of cancer compared to intact females (p = 0.001). Intact female dogs had shorter life spans than spayed female dogs (p<0.0001), but there were no differences between intact and castrated males. Intriguingly, being spayed or neutered did not affect the risk of a cancer related death but increasing age did. The most common histologic diagnosis found in golden retrievers dying of cancer was hemangiosarcoma (22.64%) followed by lymphoid neoplasia (18.40%). Overall golden retriever dogs have a substantial risk of cancer related mortality in a referral population and age appears to have a larger effect on cancer related mortality than reproductive status.
据报道，与其他犬种相比，金毛猎犬患癌症的几率更高。此外，绝育状态对寿命和患癌风险的影响也存在争议。检索了某学术中心1989年至2016年期间所有接受尸检的犬只的电子病历系统。共完成了9677例犬类尸检，其中655例为金毛猎犬。已知652例犬只的年龄，死亡中位数年龄为9.15岁。652例中有424例（65.0%）被确定因癌症死亡。非癌症原因死亡的中位数年龄为6.93岁，而因癌症死亡的中位数年龄为9.83岁（p<0.0001）。未绝育雄性和已绝育雄性死于癌症的比例没有显著差异（p = 0.43），但已绝育雌性死于癌症的比例高于未绝育雌性（p = 0.001）。未绝育雌性犬的寿命比已绝育雌性犬短（p<0.0001），但未绝育和已绝育雄性之间没有差异。有趣的是，绝育与否并不影响癌症相关死亡的风险，但年龄增长会影响。死于癌症的金毛猎犬中最常见的组织学诊断是血管肉瘤（22.64%），其次是淋巴样肿瘤（18.40%）。总体而言，在转诊犬只群体中，金毛猎犬有很大的癌症相关死亡风险，而且年龄对癌症相关死亡的影响似乎比对生殖状态的影响更大。
