Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Clin Neurophysiol. 2013 Jul;124(7):1398-405. doi: 10.1016/j.clinph.2013.01.026. Epub 2013 Apr 12.
Decreased early Bereitschaftspotential (BP) is one of the electrophysiological characteristics in patients with Parkinson's disease (PD). We examined whether PD patients could increase BP amplitude by means of neuro-feedback (NFB) training for their slow cortical potentials (SCPs).
We worked with 10 PD patients and 11 age-matched controls. BP was measured for self-paced button pressing by their right thumb. The subjects were instructed to make the introspective efforts to produce negative SCPs (negativation). The one-day session consisted of three trials, that is, the first BP, NFB training and the second BP, and each patient performed this routine for 2-4 days. Amplitudes of the first and second BPs were compared between the two groups that were divided depending on NFB performance.
Good NFB performance had the tendency of larger early BP in the second BP recording than in the first one, whereas in the poor NFB performance the early BP was smaller in the second BP recording than in the first one in both patient and normal groups (p < 0.001).
Good NFB performance of negativation could increase excitatory field potentials of pyramidal cells for the generation of early BP.
Voluntary regulation of SCPs could enhance BP in PD patients and in aged controls.
早准备电位（BP）降低是帕金森病（PD）患者的一种电生理特征。我们通过慢皮质电位（SCP）的神经反馈（NFB）训练来检查 PD 患者是否可以增加 BP 振幅。
我们与 10 名 PD 患者和 11 名年龄匹配的对照者合作。通过他们的右拇指进行自我启动按钮按压来测量 BP。指导患者进行内省努力以产生负 SCP（负向）。为期一天的会议由三个试验组成，即第一次 BP、NFB 训练和第二次 BP，每位患者进行此常规操作 2-4 天。根据 NFB 表现将两组患者进行分组，并比较第一次和第二次 BP 的振幅。
良好的 NFB 表现具有在第二次 BP 记录中比第一次记录中早 BP 更大的趋势，而在 NFB 表现不佳的情况下，患者和正常组中的第二次 BP 记录中的早 BP 比第一次记录中的早 BP 小（p <0.001）。
负向的良好 NFB 表现可以增加锥体细胞的兴奋性场电位，从而产生早 BP。
SCP 的自愿调节可以增强 PD 患者和老年对照组的 BP。
