Korting H C, Rosenkranz S
Department of Dermatology and Venereology, Ludwig-Maximilians-Universität, Munich, Germany FR.
Mycoses. 1990 Mar;33(3):136-9. doi: 10.1111/myc.1990.33.3.136.
Various recent clinical isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Epidermophyton floccosum from Munich were subjected to antimicrobial susceptibility testing using the microdilution method. Both azoles miconazole and ketoconazole were found to be more active than griseofulvin. Comparatively high inhibitory concentrations of griseofulvin were especially found with Tr. mentagrophytes. On the whole miconazole turned out to be even somewhat more effective than ketoconazole. Considering the minimum inhibitory concentrations found at least some of the strains tested might not be open to eradication in clinical terms with conventional treatment protocols.
来自慕尼黑的红色毛癣菌、须癣毛癣菌、犬小孢子菌和絮状表皮癣菌的各种近期临床分离株，采用微量稀释法进行了药敏试验。发现两种唑类药物咪康唑和酮康唑比灰黄霉素更具活性。尤其在须癣毛癣菌中发现灰黄霉素的抑制浓度相对较高。总体而言，咪康唑比酮康唑甚至稍有效一些。考虑到所发现的最低抑菌浓度，至少部分受试菌株按传统治疗方案在临床上可能无法根除。
