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1
Results of German multicenter study of antimicrobial susceptibilities of Trichophyton rubrum and Trichophyton mentagrophytes strains causing tinea unguium. German Collaborative Dermatophyte Drug Susceptibility Study Group.德国关于引起甲癣的红色毛癣菌和须癣毛癣菌菌株抗菌药敏性的多中心研究结果。德国皮肤癣菌药物敏感性协作研究组。
Antimicrob Agents Chemother. 1995 May;39(5):1206-8. doi: 10.1128/AAC.39.5.1206.
2
[Evaluation of the in vitro susceptibility pattern of clinical isolates of Trichophyton mentagrophytes and Trichophyton rubrum in Santiago, Chile].[智利圣地亚哥须发癣菌和红色毛癣菌临床分离株的体外药敏模式评估]
Rev Iberoam Micol. 2015 Apr-Jun;32(2):83-7. doi: 10.1016/j.riam.2013.12.002. Epub 2014 May 2.
3
In vitro antifungal susceptibility patterns of dermatophyte strains causing tinea unguium.引起甲癣的皮肤癣菌菌株的体外抗真菌药敏模式
Clin Exp Dermatol. 2007 Nov;32(6):675-9. doi: 10.1111/j.1365-2230.2007.02480.x. Epub 2007 Aug 22.
4
Evaluation of susceptibility of Trichophyton mentagrophytes and Trichophyton rubrum clinical isolates to antifungal drugs using a modified CLSI microdilution method (M38-A).采用改良的CLSI微量稀释法（M38 - A）评估须癣毛癣菌和红色毛癣菌临床分离株对抗真菌药物的敏感性。
J Med Microbiol. 2007 Apr;56(Pt 4):514-518. doi: 10.1099/jmm.0.46542-0.
5
In vitro antifungal oral drug and drug-combination activity against onychomycosis causative dermatophytes.体外抗真菌口服药物及药物组合对甲癣致病皮肤癣菌的活性。
Med Mycol. 2006 Jun;44(4):357-62. doi: 10.1080/13693780500536893.
6
Determination of susceptibility/resistance to antifungal drugs of Trichophyton mentagrophytes isolates by a macrodilution method.用常量稀释法测定须癣毛癣菌分离株对抗真菌药物的敏感性/耐药性
Can J Microbiol. 2005 Nov;51(11):983-7. doi: 10.1139/w05-100.
7
A new mutation in the SQLE gene of Trichophyton mentagrophytes associated to terbinafine resistance in a couple with disseminated tinea corporis.毛癣菌属中 SQLE 基因突变与特比萘芬耐药相关，导致一对夫妇播散性体癣。
J Mycol Med. 2019 Dec;29(4):352-355. doi: 10.1016/j.mycmed.2019.100903. Epub 2019 Sep 24.
8
In vitro susceptibility of Trichophyton rubrum isolates to griseofulvin and tioconazole. Induction and isolation of a resistant mutant to both antimycotic drugs. Mutant of Trichophyton rubrum resistant to griseofulvin and tioconazole.红色毛癣菌分离株对灰黄霉素和噻康唑的体外敏感性。对两种抗真菌药物耐药突变体的诱导与分离。对灰黄霉素和噻康唑耐药的红色毛癣菌突变体。
Mycopathologia. 1996;135(3):141-3. doi: 10.1007/BF00632334.
9
Evaluation of drug susceptibility test for Efinaconazole compared with conventional antifungal agents.棘白菌素类药物敏感性试验与传统抗真菌药物的比较评估。
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10
In vitro activities of antifungal drugs against dermatophytes isolated in Tokat, Turkey.土耳其托卡特分离的皮肤真菌的抗真菌药物的体外活性。
Int J Dermatol. 2013 Dec;52(12):1557-60. doi: 10.1111/ijd.12100. Epub 2013 Oct 18.

引用本文的文献

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Preparation, Characterisation, and Topical Delivery of Terbinafine.特比萘芬的制备、表征及局部给药
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[Clotrimazole and ciclopirox olamine respectively in combination with methylprednisolone aceponate as extemporaneous formulations].[克霉唑和环吡酮胺分别与糠酸莫米松联合制成临时制剂]
Hautarzt. 2017 Apr;68(4):307-315. doi: 10.1007/s00105-016-3926-8.
3
Comparison of the in vitro activities of newer triazoles and established antifungal agents against Trichophyton rubrum.新型三唑类药物与已有的抗真菌药物对红色毛癣菌的体外活性比较。
Antimicrob Agents Chemother. 2015 Jul;59(7):4312-4. doi: 10.1128/AAC.00244-15. Epub 2015 Apr 20.
4
In-vitro Activity of 10 Antifungal Agents against 320 Dermatophyte Strains Using Microdilution Method in Tehran.在德黑兰采用微量稀释法检测10种抗真菌药物对320株皮肤癣菌的体外活性。
Iran J Pharm Res. 2013 Summer;12(3):537-45.
5
Antimicrobial effects of allicin and ketoconazole on trichophyton rubrum under in vitro condition.大蒜素和酮康唑对体外红色毛癣菌的抑菌作用。
Braz J Microbiol. 2012 Apr;43(2):786-92. doi: 10.1590/S1517-83822012000200044. Epub 2012 Jun 1.
6
Antimycotic effectiveness against dermatophytes: comparison of two in vitro tests.抗真菌药物对皮肤癣菌的有效性：两种体外试验的比较。
Vet Res Commun. 2010 Jun;34 Suppl 1:S57-61. doi: 10.1007/s11259-010-9386-1.
7
[Conventional and molecular diagnosis of cutaneous mycoses].[皮肤真菌病的传统诊断与分子诊断]
Hautarzt. 2008 Dec;59(12):980-5. doi: 10.1007/s00105-008-1551-x.
8
[Mycological laboratory].[真菌学实验室]
Hautarzt. 2006 Jun;57(6):487-8, 490-2. doi: 10.1007/s00105-006-1156-1.
9
Evaluation of broth microdilution antifungal susceptibility testing conditions for Trichophyton rubrum.红色毛癣菌肉汤微量稀释抗真菌药敏试验条件的评估
J Clin Microbiol. 2005 Apr;43(4):1917-20. doi: 10.1128/JCM.43.4.1917-1920.2005.
10
Comparison of in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes by using a microdilution assay.采用微量稀释法比较17种抗真菌药物对一组20种皮肤癣菌的体外活性。
J Clin Microbiol. 2003 Oct;41(10):4817-9. doi: 10.1128/JCM.41.10.4817-4819.2003.

本文引用的文献

1
[Antimycotic drugs. Part II].
Hautarzt. 1993 Apr;44(4):257-67.
2
New approaches to the treatment of onychomycosis.甲癣治疗的新方法。
J Am Acad Dermatol. 1993 Jul;29(1):S45-50. doi: 10.1016/s0190-9622(08)81837-3.
3
Pharmacokinetic optimisation of oral antifungal therapy.口服抗真菌治疗的药代动力学优化
Clin Pharmacokinet. 1993 Oct;25(4):329-41. doi: 10.2165/00003088-199325040-00006.
4
Treatment of tinea unguium with medium and high doses of ultramicrosize griseofulvin compared with that with itraconazole.中高剂量超微粒灰黄霉素与伊曲康唑治疗甲癣的比较。
Antimicrob Agents Chemother. 1993 Oct;37(10):2064-8. doi: 10.1128/AAC.37.10.2064.
5
Griseofulvin-resistant dermatophytosis correlates with in vitro resistance.
Arch Dermatol. 1981 Jan;117(1):16-9.
6
Antimycotic susceptibility testing of dermatophytes in microcultures with a standardized fragmented mycelial inoculum.使用标准化的破碎菌丝接种物在微量培养物中对皮肤癣菌进行抗真菌药敏试验。
Antimicrob Agents Chemother. 1980 Apr;17(4):725-9. doi: 10.1128/AAC.17.4.725.
7
The activity in vitro and in vivo of a new imidazole antifungal, ketoconazole.一种新型咪唑类抗真菌药酮康唑的体内外活性
J Antimicrob Chemother. 1980 Jan;6(1):97-104. doi: 10.1093/jac/6.1.97.
8
Ketoconazole concentrations in human skin blister fluid and plasma.酮康唑在人皮肤水疱液和血浆中的浓度。
Int J Clin Pharmacol Ther Toxicol. 1984 Jul;22(7):371-4.
9
Antifungal activity of the allylamine derivative terbinafine in vitro.烯丙胺衍生物特比萘芬的体外抗真菌活性。
Antimicrob Agents Chemother. 1987 Sep;31(9):1365-8. doi: 10.1128/AAC.31.9.1365.
10
Itraconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses.伊曲康唑。对其药效学和药代动力学特性以及在浅表和全身性真菌病治疗中的应用进行综述。
Drugs. 1989 Mar;37(3):310-44. doi: 10.2165/00003495-198937030-00003.

德国关于引起甲癣的红色毛癣菌和须癣毛癣菌菌株抗菌药敏性的多中心研究结果。德国皮肤癣菌药物敏感性协作研究组。

Results of German multicenter study of antimicrobial susceptibilities of Trichophyton rubrum and Trichophyton mentagrophytes strains causing tinea unguium. German Collaborative Dermatophyte Drug Susceptibility Study Group.

作者信息

Korting H C, Ollert M, Abeck D

机构信息

Dermatologische Klinik, Ludwig-Maximilians-Universität, Munich, Germany.

出版信息

Antimicrob Agents Chemother. 1995 May;39(5):1206-8. doi: 10.1128/AAC.39.5.1206.

DOI:10.1128/AAC.39.5.1206
PMID:7625820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162715/
Abstract

Thirty-two strains of Trichophyton rubrum and 16 strains of Trichophyton mentagrophytes isolated from patients with tinea unguium in various parts of Germany were subjected to a microdilution test with six systemic or topical antimycotic agents. Apart from griseofulvin, there were no species-specific differences between the two species. Terbinafine was the most active antimycotic agent, with a MIC not exceeding 0.05 micrograms/ml.

摘要

从德国各地甲癣患者中分离出的32株红色毛癣菌和16株须癣毛癣菌，用六种全身或局部抗真菌药物进行了微量稀释试验。除灰黄霉素外，这两种菌之间没有种属特异性差异。特比萘芬是最有效的抗真菌药物，其最低抑菌浓度不超过0.05微克/毫升。