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2013 年 2 月至 4 月期间从中国患者中分离出的新型甲型 H7N9 流感病毒的基因分析。

Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013.

机构信息

Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

出版信息

Euro Surveill. 2013 Apr 11;18(15):20453.

PMID:23594575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6296756/
Abstract

Novel influenza viruses of the H7N9 subtype have infected 33 and killed nine people in China as of 10 April 2013. Their haemagglutinin (HA) and neuraminidase genes probably originated from Eurasian avian influenza viruses; the remaining genes are closely related to avian H9N2 influenza viruses. Several characteristic amino acid changes in HA and the PB2 RNA polymerase subunit probably facilitate binding to human-type receptors and efficient replication in mammals, respectively, highlighting the pandemic potential of the novel viruses.

摘要

截至 2013 年 4 月 10 日，中国已确诊感染新型 H7N9 亚型流感病毒的患者 33 例，死亡 9 例。其血凝素（HA）和神经氨酸酶基因可能源自欧亚大陆的禽流感病毒；其余基因与禽 H9N2 流感病毒密切相关。HA 中的几个特征性氨基酸变化和 PB2 RNA 聚合酶亚基可能分别有助于与人类型受体结合和在哺乳动物中有效复制，突出了新型病毒的大流行潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/72d1c6ddc0d7/nihms-989744-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/ca8d5fba2842/nihms-989744-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/a029f93fd882/nihms-989744-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/5861f850b9ba/nihms-989744-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/72d1c6ddc0d7/nihms-989744-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/ca8d5fba2842/nihms-989744-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/a029f93fd882/nihms-989744-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/5861f850b9ba/nihms-989744-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d5/6296756/72d1c6ddc0d7/nihms-989744-f0010.jpg

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1
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PLoS One. 2013;8(2):e49597. doi: 10.1371/journal.pone.0049597. Epub 2013 Feb 20.
2
Influenza a viruses from wild birds in Guatemala belong to the North American lineage.危地马拉野生鸟类中的甲型流感病毒属于北美谱系。
PLoS One. 2012;7(3):e32873. doi: 10.1371/journal.pone.0032873. Epub 2012 Mar 13.
3
Low pathogenic H7 subtype avian influenza viruses isolated from domestic ducks in South Korea and the close association with isolates of wild birds.
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PLoS Pathog. 2024 Oct 22;20(10):e1012427. doi: 10.1371/journal.ppat.1012427. eCollection 2024 Oct.
4
Simultaneous Differential Detection of H5, H7, H9 and Nine NA Subtypes of Avian Influenza Viruses via a GeXP Assay.通过GeXP分析法同时鉴别检测禽流感病毒的H5、H7、H9及9种神经氨酸酶亚型
Microorganisms. 2024 Jan 11;12(1):143. doi: 10.3390/microorganisms12010143.
5
The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir.PA/I38 取代和 PA 多态性对人畜共患流感 A 病毒对巴洛沙韦敏感性的影响。
Arch Virol. 2024 Jan 12;169(2):29. doi: 10.1007/s00705-023-05958-5.
6
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Emerg Microbes Infect. 2024 Dec;13(1):2284301. doi: 10.1080/22221751.2023.2284301. Epub 2024 Jan 4.
7
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NPJ Vaccines. 2023 Mar 24;8(1):46. doi: 10.1038/s41541-023-00643-9.
8
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Life (Basel). 2022 Aug 27;12(9):1326. doi: 10.3390/life12091326.
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Iran J Vet Res. 2021 Fall;22(4):352-355. doi: 10.22099/IJVR.2021.41104.5964.
从韩国家养鸭中分离到的低致病性 H7 亚型禽流感病毒与野鸟分离株的密切关系。
J Gen Virol. 2012 Jun;93(Pt 6):1278-1287. doi: 10.1099/vir.0.041269-0. Epub 2012 Mar 14.
4
Influenza A (H5N1) viruses from pigs, Indonesia.来自印度尼西亚猪的甲型流感（H5N1）病毒。
Emerg Infect Dis. 2010 Oct;16(10):1515-23. doi: 10.3201/eid1610.100508.
5
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PLoS Pathog. 2010 Sep 2;6(9):e1001081. doi: 10.1371/journal.ppat.1001081.
6
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J Virol. 2010 Jul;84(13):6570-7. doi: 10.1128/JVI.00221-10. Epub 2010 Apr 28.
7
Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice.神经氨酸酶茎部长度和血凝素的额外糖基化影响H5N1流感病毒对小鼠的毒力。
J Virol. 2009 May;83(9):4704-8. doi: 10.1128/JVI.01987-08. Epub 2009 Feb 18.
8
Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice.基质蛋白M1中的两个氨基酸残基导致H5N1禽流感病毒在小鼠中的毒力差异。
Virology. 2009 Feb 5;384(1):28-32. doi: 10.1016/j.virol.2008.11.044. Epub 2008 Dec 30.
9
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Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4381-6. doi: 10.1073/pnas.0800482105. Epub 2008 Mar 11.
10
A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice.NS1蛋白中的单个氨基酸替换改变了H5N1禽流感病毒在小鼠中的致病性。
J Virol. 2008 Feb;82(3):1146-54. doi: 10.1128/JVI.01698-07. Epub 2007 Nov 21.