Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Euro Surveill. 2013 Apr 11;18(15):20453.
Novel influenza viruses of the H7N9 subtype have infected 33 and killed nine people in China as of 10 April 2013. Their haemagglutinin (HA) and neuraminidase genes probably originated from Eurasian avian influenza viruses; the remaining genes are closely related to avian H9N2 influenza viruses. Several characteristic amino acid changes in HA and the PB2 RNA polymerase subunit probably facilitate binding to human-type receptors and efficient replication in mammals, respectively, highlighting the pandemic potential of the novel viruses.
截至 2013 年 4 月 10 日,中国已确诊感染新型 H7N9 亚型流感病毒的患者 33 例,死亡 9 例。其血凝素(HA)和神经氨酸酶基因可能源自欧亚大陆的禽流感病毒;其余基因与禽 H9N2 流感病毒密切相关。HA 中的几个特征性氨基酸变化和 PB2 RNA 聚合酶亚基可能分别有助于与人类型受体结合和在哺乳动物中有效复制,突出了新型病毒的大流行潜力。