泼尼松对健康人血脑屏障通透性及中枢神经系统IgG合成的影响。

Prednisone effects on blood-brain barrier permeability and CNS IgG synthesis in healthy humans.

作者信息

Wolkowitz O M, Papadopoulos N M, Costello R, Breier A, Doran A R, Pickar D, Rubinow D

机构信息

University of California, Department of Psychiatry, San Francisco.

出版信息

Psychoneuroendocrinology. 1990;15(2):155-8. doi: 10.1016/0306-4530(90)90024-4.

DOI:10.1016/0306-4530(90)90024-4

PMID:2359811

Abstract

Corticosteroids reportedly decrease blood-brain barrier (BBB) permeability and/or IgG synthesis in patients with multiple sclerosis or brain tumors. However, these effects have not been studied in healthy humans. We investigated the effects of prednisone, 80 mg/day for five days, on the ratio of cerebrospinal fluid (CSF) albumin/serum albumin, a measure of blood-brain barrier (BBB) permeability, and on CSF and serum IgG levels in six healthy, normal volunteers. We found significant steroid-induced decreases in serum and CSF albumin levels and in serum IgG levels. However, we found only a nonsignificant decrease in BBB permeability and no significant change in CNS IgG synthesis. These findings, based on a small number of volunteers, suggest that it may be difficult to further decrease BBB permeability and CNS IgG synthesis in medically healthy subjects.

摘要

据报道，皮质类固醇可降低多发性硬化症或脑肿瘤患者的血脑屏障（BBB）通透性和/或IgG合成。然而，这些作用尚未在健康人体中进行研究。我们调查了连续五天每天服用80毫克泼尼松对六名健康正常志愿者的脑脊液（CSF）白蛋白/血清白蛋白比值（一种血脑屏障（BBB）通透性的测量指标）以及脑脊液和血清IgG水平的影响。我们发现，类固醇导致血清和脑脊液白蛋白水平以及血清IgG水平显著下降。然而，我们发现血脑屏障通透性仅出现非显著性降低，中枢神经系统IgG合成无显著变化。基于少数志愿者的这些发现表明，在医学上健康的受试者中可能难以进一步降低血脑屏障通透性和中枢神经系统IgG合成。