Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.
Eye (Lond). 2013 Jul;27(7):809-15. doi: 10.1038/eye.2013.78. Epub 2013 Apr 19.
To evaluate the variability in subfoveal choroidal thickness measurements in patients with age-related macular degeneration (AMD) and central serous chorioretinopathy using enhanced depth imaging optical coherence tomography (EDI-OCT).
One hundred and sixty eyes of 160 patients who were diagnosed with early AMD (N=40), exudative AMD (N=40), polypoidal choroidal vasculopathy (PCV, N=40), or central serous chorioretinopathy (CSC, N=40) were included in this retrospective observational study. In addition, we included 40 normal eyes of 40 subjects. Subfoveal choroidal thickness was measured manually by two masked observers based on EDI-OCT images. The correlation of choroidal thickness with the absolute value of the difference in the choroidal thickness measurement was estimated for all 200 eyes. Intraobserver and interobserver coefficients of repeatability (CRs) were calculated.
There was a significant positive correlation between subfoveal choroidal thickness and both intraobserver (P<0.001) and interobserver (P<0.001) difference in choroidal thickness measurements. The mean intraobserver CRs in nonexudative AMD, exudative AMD, PCV, CSC, and normal eyes were ~15-21, 23-29, 24-35, 32-38, and 19-25 μm, respectively. The mean interobserver CRs were ~24-28, 30-36, 39-45, 46-57, and 26-35 μm, respectively.
Relatively great measurement variability should be considered when investigating eyes with pathologic conditions related to a thick choroid, including PCV or CSC.
使用增强深度成像光学相干断层扫描（EDI-OCT）评估年龄相关性黄斑变性（AMD）和中心性浆液性脉络膜视网膜病变患者的脉络膜厚度的变异性。
本回顾性观察研究纳入了 160 名被诊断为早期 AMD（N=40）、渗出性 AMD（N=40）、息肉状脉络膜血管病变（PCV，N=40）或中心性浆液性脉络膜视网膜病变（CSC，N=40）的患者的 160 只眼，以及 40 名健康受试者的 40 只眼。两名掩蔽观察者根据 EDI-OCT 图像手动测量中心凹下脉络膜厚度。对所有 200 只眼的脉络膜厚度与脉络膜厚度测量的绝对值差异的相关性进行了估计。计算了观察者内和观察者间的可重复性（CR）系数。
中心凹下脉络膜厚度与观察者内（P<0.001）和观察者间（P<0.001）的脉络膜厚度差异均呈显著正相关。在非渗出性 AMD、渗出性 AMD、PCV、CSC 和正常眼中，观察者内 CR 的平均值分别约为 15-21、23-29、24-35、32-38 和 19-25μm。观察者间 CR 的平均值分别约为 24-28、30-36、39-45、46-57 和 26-35μm。
在研究与脉络膜增厚相关的病理情况（包括 PCV 或 CSC）的眼睛时，应考虑较大的测量变异性。
