Chen Guohai, Tzekov Radouil, Li Wensheng, Jiang Fangzheng, Mao Sihong, Tong Yuhua
Department of Ophthalmology, Quzhou People's Hospital, Quzhou, Zhejiang, PR China.
Department of Ophthalmology, University of South Florida, Tampa, Florida, United States of America.
PLoS One. 2017 Jan 11;12(1):e0169152. doi: 10.1371/journal.pone.0169152. eCollection 2017.
To evaluate the relationship between subfoveal choroidal thickness (SFCT) and eyes with central serous chorioretinopathy (CSC) versus fellow or control eyes.
We performed a meta-analysis using databases including PubMed, Embase and ISI Web of Science to find relevant studies. Weighted mean difference (WMD) was calculated for the SFCT in CSC eyes, the unaffected fellow eyes and normal controls.
Twelve studies were selected for this meta-analysis, including 1108 eyes (397 CSC eyes, 228 unaffected fellow eyes and 483 eyes of normal controls). The meta-analysis clearly demonstrated that the subfoveal choiroid of eyes with a clinical presentation of CSC was thickened compared to unaffected fellow eyes (WMD = 52.81, 95% confidence interval (CI), 39.13-66.49, P<0.00001) and was thickened compared to control eyes (WMD = 145.03, 95%CI, 121.33-168.73, P<0.00001). The mean SFCT measurement of the unaffected fellow eyes showed also significantly increased choroidal thickness compared to that of normal control eyes (WMD = 77.20, 95% CI, 44.98-109.42, P<0.00001). Similar results were obtained in a sub-analysis based on the same instrument.
It is demonstrated that SFCT is significantly increased in eyes with clinical manifestation of CSC, and in the clinically non-manifested fellow eyes. These results support the hypothesis that CSC is a bilateral disorder with an initial unilateral clinical presentation.
评估中心性浆液性脉络膜视网膜病变（CSC）患眼的黄斑下脉络膜厚度（SFCT）与对侧眼或对照眼之间的关系。
我们使用包括PubMed、Embase和ISI科学网在内的数据库进行荟萃分析，以查找相关研究。计算CSC患眼、未受影响的对侧眼和正常对照眼中SFCT的加权平均差（WMD）。
本荟萃分析选取了12项研究，包括1108只眼（397只CSC患眼、228只未受影响的对侧眼和483只正常对照眼）。荟萃分析清楚地表明，与未受影响的对侧眼相比，临床表现为CSC的患眼黄斑下脉络膜增厚（WMD = 52.81，95%置信区间（CI），39.13 - 66.49，P < 0.00001），与对照眼相比也增厚（WMD = 145.03，95%CI，121.33 - 168.73，P < 0.00001）。未受影响的对侧眼的平均SFCT测量值与正常对照眼相比，脉络膜厚度也显著增加（WMD = 77.20，95%CI，44.98 - 109.42，P < 0.00001）。基于同一仪器的亚分析也得到了类似结果。
结果表明，CSC临床表现患眼以及临床未表现的对侧眼中SFCT均显著增加。这些结果支持CSC是一种双侧性疾病但最初表现为单侧临床症状的假说。
