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肿瘤间质比是非小细胞肺癌的独立预后因素。

[Tumor-stroma ratio is an independent prognostic factor of non-small cell lung cancer].

作者信息

Wang Zhaofeng, Liu Hongbing, Zhao Rende, Zhang He, Liu Chunhua, Song Yong

机构信息

Department of Respiratory Medicine, Nanjing General Hospital of Nanjing Command, Clinical School of the Medical College of Nanjing University, Nanjing 210002, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2013 Apr;16(4):191-6. doi: 10.3779/j.issn.1009-3419.2013.04.04.

DOI:10.3779/j.issn.1009-3419.2013.04.04
PMID:23601299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6000589/
Abstract

BACKGROUND

The different expression of tumor-stroma ratio (TSR) have been proved to be a new and reliable independent prognostic factor in some solid tumors.The aim of the study is to test the different expression of TSR and its prognostic significance in non-small cell lung cancer (NSCLC).

METHODS

A total of 73 patients who underwent surgery resection for NSCLC were included in this study. TSR was assessed visually on the hematoxylin-stained tissue sections of surgical specimens. Patients with more than 50% intratumor stroma were quantified as the stroma-rich group and those with less than 50% as the stroma-poor group.

RESULTS

In 73 cases of tissue samples, 46 cases were included in the stroma-poor group, while 27 cases in stroma-rich group. The different expression of TSR in NSCLC tissue was not correlated with gender, age and pathological type, lymph node metastasis, tumor size, pTNM staging, and so on. Kaplan-Meier survival analysis showed that the different expression of TSR was significantly correlated with survival days (P=0.014). Cox regression analysis showed that not only different expression of TSR is a independent prognostic factor for NSCLC (HR=1.832, 95%CI: 1.017-3.299), but also pTNM staging (HR=1.953, 95%CI: 1.284-2.970).

CONCLUSIONS

The different expression of TSR might be an independent prognostic factor in NSCLC.

摘要

背景

肿瘤间质比（TSR）的不同表达已被证明是一些实体瘤中一种新的、可靠的独立预后因素。本研究的目的是检测TSR在非小细胞肺癌（NSCLC）中的不同表达及其预后意义。

方法

本研究共纳入73例行NSCLC手术切除的患者。在手术标本的苏木精染色组织切片上直观评估TSR。肿瘤内间质超过50%的患者被量化为富间质组，低于50%的患者为贫间质组。

结果

在73例组织样本中，贫间质组有46例，富间质组有27例。NSCLC组织中TSR的不同表达与性别、年龄、病理类型、淋巴结转移、肿瘤大小、pTNM分期等无关。Kaplan-Meier生存分析显示，TSR的不同表达与生存天数显著相关（P = 0.014）。Cox回归分析表明，TSR的不同表达不仅是NSCLC的独立预后因素（HR = 1.832，95%CI：1.017 - 3.299），而且pTNM分期也是（HR = 1.953，95%CI：1.284 - 2.970）。

结论

TSR的不同表达可能是NSCLC的独立预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8b/6000589/4a9ebc9d8282/zgfazz-16-4-191-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8b/6000589/06b5c88ad818/zgfazz-16-4-191-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8b/6000589/4a9ebc9d8282/zgfazz-16-4-191-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8b/6000589/06b5c88ad818/zgfazz-16-4-191-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8b/6000589/4a9ebc9d8282/zgfazz-16-4-191-2.jpg

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