Youssef R Z, Murray M, Holmes B, Mogabgab W J
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112.
Sex Transm Dis. 1990 Apr-Jun;17(2):99-101. doi: 10.1097/00007435-199004000-00011.
The authors compared the safety and efficacy of 0.5 and 1.0 g of cefotetan with that of 0.25 g of ceftriaxone in a 3:3:2 randomized distribution. Of 172 patients (96 men, 76 women) aged 18-43 years who were being treated at the Delgado Venereal Disease Clinic, New Orleans Health Department, for acute gonococcal urethritis or cervicitis, 123 were evaluable (81 men, 42 women). All men and 16 women were initially symptomatic. All were culture positive for Neisseria gonorrhoeae. At the 4-8 day follow-up, cultures were negative for N. gonorrhoeae in all except one man and one woman, each of whom received cefotetan 0.5 g. Symptoms were eliminated 12-72 hr after therapy in all groups. Cefotetan was well tolerated, and there were few adverse experiences reported. Thus, the authors consider cefotetan safe and effective for the treatment of uncomplicated gonorrhea.
作者以3:3:2的随机分布比例，比较了0.5克和1.0克头孢替坦与0.25克头孢曲松的安全性和有效性。在新奥尔良市卫生部门德尔加多性病诊所接受急性淋菌性尿道炎或宫颈炎治疗的172例年龄在18至43岁的患者（96名男性，76名女性）中，123例可进行评估（81名男性，42名女性）。所有男性和16名女性最初均有症状。所有患者淋病奈瑟菌培养均为阳性。在4至8天的随访中，除1名男性和1名女性外，所有人的淋病奈瑟菌培养均为阴性，这两名患者均接受了0.5克头孢替坦治疗。所有组的症状在治疗后12至72小时内均消失。头孢替坦耐受性良好，报告的不良事件很少。因此，作者认为头孢替坦治疗单纯性淋病安全有效。
