Xenobiochemistry Dept.- National Reference Laboratory for Biomarkers of Mycotoxins and Mycotoxins in Food, Regional Hygiene Station, Nezvalova 958, 500 02, Hradec Kralove, Czech Republic.
Mycotoxin Res. 2001 Jun;17 Suppl 2:129-31. doi: 10.1007/BF03036420.
Standard dialysis did not result in a decrease of the OTA level in the blood serum of patients regularly treated by dialysis. Therefore, we examined the effect of dialysis on both OTA bound to the blood plasma proteins and free OTA. We carried out an in vivo experiment to determine OTA levels in the serum of patients in the terminal stage of chronic renal insufficiency (CHRI) before and after dialysis and also in the dialysate in which we did not find OTA. OTA bound to blood plasma proteins did not penetrate the dialysis membrane. In contrast, free OTA during an in vitro experiment with the identical dialyzer (as during the in vivo experiment), easily penetrated the same dialysis membrane.
常规透析并未降低定期接受透析治疗的患者血清中的 OTA 水平。因此，我们研究了透析对与血浆蛋白结合的 OTA 和游离 OTA 的影响。我们进行了一项体内实验，以确定慢性肾功能不全（CHRI）终末期患者透析前后血清以及我们未发现 OTA 的透析液中的 OTA 水平。与血浆蛋白结合的 OTA 无法穿透透析膜。相反，在与体内实验相同的透析器进行的体外实验中，游离 OTA 很容易穿透相同的透析膜。
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