Dambska M, Laure-Kamionowska M
Medical Research Centre, Polish Academy of Science, Warsaw, Poland.
Brain Dev. 1990;12(2):214-20. doi: 10.1016/s0387-7604(12)80328-7.
In this study a comparison of the myelination rate in humans in normal and pathologic conditions was made. The progress of myelination was examined on slides stained by the Klüver-Barrera method and evaluated as to four degrees. The prenatal myelination in the brain stem in a group of newborns who died of pregnancy pathology was correlated with normal brain stem myelination. Retardation of myelination by 2 to 10 weeks was found in cases with gestosis and diabetes in anamnesia. The myelin sheath formation in a group of children who died during the first three years of life after severe chronic diseases neoplastic and congenital heart failure was compared with the normal rate of postnatal myelination of the temporal lobe. The myelination process was evidently retarded by 2 to 20 months. The observations presented in this paper allowed the conclusion that pathologic conditions occurring in the maturing human may cause retarded maturation of myelin sheath.
在本研究中，对人类在正常和病理条件下的髓鞘形成速率进行了比较。通过Klüver-Barrera方法染色的载玻片上检查髓鞘形成的进展，并评估为四个程度。一组死于妊娠病理的新生儿脑干中的产前髓鞘形成与正常脑干髓鞘形成相关。有妊娠中毒症和糖尿病病史的病例中发现髓鞘形成延迟2至10周。将一组在严重慢性疾病（肿瘤和先天性心力衰竭）后生命的前三年中死亡的儿童的髓鞘形成与颞叶产后髓鞘形成的正常速率进行比较。髓鞘形成过程明显延迟2至20个月。本文提出的观察结果得出结论，成熟人类中发生的病理状况可能导致髓鞘成熟延迟。
