Staudt M, Schropp C, Staudt F, Obletter N, Bise K, Breit A, Weinmann H M
Kinderklinik Dritter Orden, Passau, Germany.
Pediatr Radiol. 1994;24(2):122-7. doi: 10.1007/BF02020169.
777 cerebral MRI examinations of children aged 3 days to 14 years were staged for myelination to establish an age standardization. Staging was performed using a system proposed in a previous paper, separately ranking 10 different regions of the brain. Interpretation of the results led to the identification of four clinical diagnoses that are frequently associated with delays in myelination: West syndrome, cerebral palsy, developmental retardation, and congenital anomalies. In addition, it was found that assessment of myelination in children with head injuries was not practical as alterations in MRI signal can simulate earlier stages of myelination. Age limits were therefore calculated from the case material after excluding all children with these conditions. When simplifications of the definition of the stages are applied, these age limits for the various stages of myelination of each of the 10 regions of the brain make the staging system applicable for routine assessment of myelination.
对777例年龄在3天至14岁的儿童进行脑部MRI检查，根据髓鞘形成情况进行分期，以建立年龄标准化。分期采用先前一篇论文中提出的系统，分别对大脑的10个不同区域进行排名。对结果的解读导致确定了四种经常与髓鞘形成延迟相关的临床诊断：韦斯特综合征、脑瘫、发育迟缓以及先天性异常。此外，发现对头部受伤儿童进行髓鞘形成评估并不实用，因为MRI信号改变可模拟髓鞘形成的早期阶段。因此，在排除所有患有这些病症的儿童后，根据病例资料计算出年龄界限。当对分期定义进行简化时，大脑10个区域中每个区域髓鞘形成不同阶段的这些年龄界限使得该分期系统适用于髓鞘形成的常规评估。
