Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, 1081BT, The Netherlands.
Trends Immunol. 2013 Oct;34(10):482-6. doi: 10.1016/j.it.2013.03.001. Epub 2013 Apr 20.
The innate immune receptor DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin) was discovered over a decade ago and was initially identified as a pattern recognition receptor. In addition to its ability to recognize a broad range of pathogen-derived ligands and self-glycoproteins, DC-SIGN also mediates intercellular adhesion, as well as antigen uptake and signaling, which is a functional hallmark of dendritic cells (DCs). Most research on DC-SIGN has relied on in vitro studies. The in vivo function of DC-SIGN is difficult to address, in part because there are eight genetic homologs in mice with no clear DC-SIGN ortholog. Here, we summarize the functions attributed to DC-SIGN based on in vitro data and discuss the limitations of available mouse models to uncover the physiological role of this receptor in vivo.
十多年前发现了先天免疫受体 DC-SIGN（树突状细胞特异性细胞间黏附分子 3 抓取非整联蛋白），最初被鉴定为一种模式识别受体。除了能够识别广泛的病原体衍生配体和自身糖蛋白外，DC-SIGN 还介导细胞间黏附以及抗原摄取和信号转导，这是树突状细胞（DC）的功能标志。大多数关于 DC-SIGN 的研究都依赖于体外研究。DC-SIGN 的体内功能难以解决，部分原因是小鼠中有 8 个遗传同源物，没有明确的 DC-SIGN 直系同源物。在这里，我们根据体外数据总结了归因于 DC-SIGN 的功能，并讨论了现有小鼠模型的局限性，以揭示该受体在体内的生理作用。
