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耐甲氧西林金黄色葡萄球菌临界株的进一步鉴定及青霉素结合蛋白分析

Further characterization of borderline methicillin-resistant Staphylococcus aureus and analysis of penicillin-binding proteins.

作者信息

Montanari M P, Tonin E, Biavasco F, Varaldo P E

机构信息

Institute of Microbiology, University of Ancona Medical School, Italy.

出版信息

Antimicrob Agents Chemother. 1990 May;34(5):911-3. doi: 10.1128/AAC.34.5.911.

DOI:10.1128/AAC.34.5.911
PMID:2360829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171719/
Abstract

Eighty-nine Staphylococcus aureus strains were grouped according to their susceptibility or resistance to methicillin and oxacillin. The role of beta-lactamase in borderline methicillin resistance was confirmed by tests with beta-lactamase inhibitors, particularly when salt-supplemented medium was used. A penicillin-binding protein assay indicated that borderline methicillin-resistant S. aureus strains do not produce PBP 2a.

摘要

89株金黄色葡萄球菌根据其对甲氧西林和苯唑西林的敏感性或耐药性进行分组。通过使用β-内酰胺酶抑制剂进行测试，证实了β-内酰胺酶在临界甲氧西林耐药中的作用，特别是在使用补充盐的培养基时。青霉素结合蛋白分析表明，临界甲氧西林耐药的金黄色葡萄球菌菌株不产生PBP 2a。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dfa/171719/11b52adab695/aac00061-0267-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dfa/171719/88ad6d8759a8/aac00061-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dfa/171719/11b52adab695/aac00061-0267-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dfa/171719/88ad6d8759a8/aac00061-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dfa/171719/11b52adab695/aac00061-0267-a.jpg

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本文引用的文献

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Identification, clinical distribution, and susceptibility to methicillin and 18 additional antibiotics of clinical Staphylococcus isolates: nationwide investigation in Italy.临床葡萄球菌分离株的鉴定、临床分布以及对甲氧西林和另外18种抗生素的敏感性：意大利全国性调查
J Clin Microbiol. 1984 Jun;19(6):838-43. doi: 10.1128/jcm.19.6.838-843.1984.
2
Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.与金黄色葡萄球菌β-内酰胺耐药性相关的低亲和力青霉素结合蛋白。
J Bacteriol. 1984 May;158(2):513-6. doi: 10.1128/jb.158.2.513-516.1984.
3
Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin.
南非恩孔科比市农场动物源葡萄球菌的物种多样性和抗生素抗性特性
Folia Microbiol (Praha). 2014 Mar;59(2):133-40. doi: 10.1007/s12223-013-0275-1. Epub 2013 Sep 5.
4
Dutch guideline on the laboratory detection of methicillin-resistant Staphylococcus aureus.荷兰耐甲氧西林金黄色葡萄球菌实验室检测指南。
Eur J Clin Microbiol Infect Dis. 2014 Jan;33(1):89-101. doi: 10.1007/s10096-013-1933-6. Epub 2013 Jul 27.
5
Analysis of borderline oxacillin-resistant Staphylococcus aureus (BORSA) strains isolated in Tunisia.分析突尼斯分离的耐苯唑西林边缘型金黄色葡萄球菌（BORSA）菌株。
J Clin Microbiol. 2012 Oct;50(10):3345-8. doi: 10.1128/JCM.01354-12. Epub 2012 Jul 18.
6
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.英国和丹麦人群及牛群中新型 mecA 同源物的耐甲氧西林金黄色葡萄球菌：描述性研究。
Lancet Infect Dis. 2011 Aug;11(8):595-603. doi: 10.1016/S1473-3099(11)70126-8.
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Distribution of mecA among methicillin-resistant clinical staphylococcal strains isolated at hospitals in Naples, Italy.意大利那不勒斯各医院分离出的耐甲氧西林临床葡萄球菌菌株中mecA基因的分布情况。
Eur J Epidemiol. 2003;18(2):139-45. doi: 10.1023/a:1023067930211.
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Direct mecA detection from blood culture bottles by branched-DNA signal amplification.通过分支DNA信号放大技术直接从血培养瓶中检测mecA基因。
J Clin Microbiol. 1999 Dec;37(12):4192-3. doi: 10.1128/JCM.37.12.4192-4193.1999.
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在一株耐甲氧西林金黄色葡萄球菌暴露于萘夫西林后，一种新型青霉素结合蛋白的量增加。
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