Women's Integrated Healthcare Center (CAISM), Universidade Estadual de Campinas (Unicamp), São Paulo, Brazil.
Clin Rheumatol. 2013 Nov;32(11):1585-92. doi: 10.1007/s10067-013-2265-8. Epub 2013 Apr 23.
To validate the Portuguese version of the quality of life questionnaire of the European foundation for osteoporosis (QUALEFFO-41) in Brazilian women with osteoporotic vertebral fractures (VF). A questionnaire validation study of 86 postmenopausal women was conducted. Women were divided into two groups: 43 in a group with VF and 43 in a group without osteoporosis, age-matched (±3 years). The QUALEFFO-41 questionnaire was administered twice in 4 weeks and compared to a generic questionnaire SF-36. For analysis of the QUALEFFO-41, internal consistency, repeatability, and discriminant capacity between VF patients and control patients were assessed. The significance level adopted was 5 %. The mean age of the women was 66.1 ± 7.2 years for the group with VF and 64.9 ± 6.3 years for the control group (p = 0.4259). The QUALEFFO showed adequate internal consistency in all domains (Cronbach's α of 0.74 to 0.84) and good repeatability (ICC of domains = 0.67-0.90). Of the total questions, 92.6 % demonstrated satisfactory convergent validity, and 95 % of the questions showed good discriminant validity. The mean scores of both questionnaires were significantly higher in the group with VF. There was a good correlation among the QUALEFFO-41 domains and their corresponding SF-36 domains, except for social function. All QUALEFFO-41 domains were significantly predictive of VF on assessment of the ROC curve. The Portuguese version of the QUALEFFO-41 may be used in Brazilian women with osteoporotic VF because it shows good reliability, repeatability, and validity. It was also shown to impair quality of life (QOL) in women with VF and had good ability to discriminate QOL in women with osteoporotic VF.
为了验证欧洲骨质疏松基金会（Osteoporosis Foundation of Europe，EOF）的生活质量问卷（Quality of Life Questionnaire of the European Foundation for Osteoporosis，QUALEFFO-41）的葡萄牙版本在巴西患有骨质疏松性椎体骨折（vertebral fractures，VF）的女性中的适用性。进行了一项包含 86 名绝经后女性的问卷调查验证研究。这些女性被分为两组：一组 43 人患有 VF，另一组 43 人患有骨质疏松症，年龄匹配（±3 岁）。在 4 周内两次使用 QUALEFFO-41 问卷，并与一般问卷 SF-36 进行比较。为了分析 QUALEFFO-41，评估了其内部一致性、重复性和 VF 患者与对照组患者之间的区分能力。采用的显著性水平为 5%。VF 组女性的平均年龄为 66.1±7.2 岁，对照组为 64.9±6.3 岁（p=0.4259）。QUALEFFO 在所有领域都具有足够的内部一致性（Cronbach's α 为 0.74 至 0.84），并且具有良好的重复性（领域内的 ICC 为 0.67-0.90）。在所有问题中，92.6%的问题具有令人满意的收敛有效性，95%的问题具有良好的区分有效性。VF 组的两个问卷的平均得分均显著较高。在 QUALEFFO-41 领域及其相应的 SF-36 领域之间存在良好的相关性，除了社会功能。在评估 ROC 曲线时，所有 QUALEFFO-41 领域均能显著预测 VF。在巴西患有骨质疏松性 VF 的女性中，可以使用 QUALEFFO-41 的葡萄牙版本，因为它具有良好的可靠性、重复性和有效性。它还表明，患有 VF 的女性的生活质量（quality of life，QOL）受到损害，并且对患有骨质疏松性 VF 的女性的 QOL 具有良好的区分能力。
