1Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University , Chongqing , China.
Int J Neurosci. 2013 Oct;123(10):675-83. doi: 10.3109/00207454.2013.798784. Epub 2013 Jun 20.
Epidemiological studies have evaluated the associations between brain-derived neurotrophic factor (BDNF) polymorphisms and Parkinson's disease (PD) risk. However, the results remain inconsistent. Therefore, we conducted a meta-analysis of published case-control studies to better understand these results. Systematic searches of electronic databases Embase, PubMed and Web of Science, as well as hand searching of the references of identified articles were performed. The pooled odds ratio (OR) with 95% confidence interval (CI) were calculated. All the statistical tests were performed using Review Manager 5.1 and Stata 11.0. A total of 13 case-control studies were included, involving two polymorphisms (G196A and C270T) of BDNF gene and covering 3333 PD cases and 3418 controls. No significant associations were found on the overall analysis both G196A and C270T polymorphisms. In the subgroup analysis by ethnicity (Caucasian, Asian and Mixed population), there were still no detectable associations. In conclusion, there is no enough evidence for associations between BDNF polymorphisms (G196A and C270T) and PD risk at present. Larger sample-size and multiethnicity studies with homogeneous PD patients and well-matched controls are needed in the future study.
流行病学研究评估了脑源性神经营养因子（BDNF）多态性与帕金森病（PD）风险之间的关联。然而，结果仍然不一致。因此，我们对已发表的病例对照研究进行了荟萃分析，以更好地理解这些结果。系统地检索了 Embase、PubMed 和 Web of Science 电子数据库，并手动检索了已确定文章的参考文献。使用 Review Manager 5.1 和 Stata 11.0 计算了合并的优势比（OR）和 95%置信区间（CI）。所有的统计检验均采用 Review Manager 5.1 和 Stata 11.0 进行。共纳入了 13 项病例对照研究，涉及 BDNF 基因的两个多态性（G196A 和 C270T），涵盖了 3333 例 PD 病例和 3418 例对照。总体分析未发现 G196A 和 C270T 多态性与 PD 风险之间存在显著关联。按种族（白种人、亚洲人和混合人群）进行亚组分析，仍未发现可检测到的关联。总之，目前没有足够的证据表明 BDNF 多态性（G196A 和 C270T）与 PD 风险之间存在关联。未来的研究需要更大的样本量和多民族研究，并且需要具有同质 PD 患者和匹配良好的对照。
