Lee Young Ho, Song Gwan Gyu
a Division of Rheumatology, Department of Internal Medicine , Korea University College of Medicine , Seoul.
J Mot Behav. 2014;46(1):59-66. doi: 10.1080/00222895.2013.862199. Epub 2013 Dec 12.
ABSTRACT The aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) polymorphisms 196 G/A and 270 C/T confer susceptibility to Parkinson's disease (PD). The authors conducted a meta-analysis of the associations between the BDNF 196 G/A and 270 C/T polymorphisms and PD in subjects. They considered 12 studies in the case of the BDNF 196 G/A polymorphism and 4 studies in the case of the BDNF 270 C/T polymorphism. Meta-analysis showed no association between PD and the BDNF 196A allele in all study subjects (odds ratio [OR] = 1.066, 95% CI [0.972, 1.169], p = .173). However, ethnicity-specific meta-analysis identified an association between the BDNF 196 AA + AG genotype and PD in Europeans, but not in Asians (OR = 1.212, 95% CI [1.007, 1.458], p = .042; OR = 1.0567, 95% CI [0.913, 1.221], p = .465). Meta-analysis showed no association between PD and the BDNF 270 C/T polymorphism (OR for the T allele = 1.213, 95% CI [0.923, 1.595], p = .165). This meta-analysis identified an association between the BDNF 196 G/A polymorphism in Europeans, but not in Asians, but failed to identify an association between the BDNF 270 C/T polymorphism and PD.
摘要 本研究旨在探讨脑源性神经营养因子（BDNF）基因多态性196 G/A和270 C/T是否与帕金森病（PD）易感性相关。作者对BDNF 196 G/A和270 C/T基因多态性与PD之间的关联进行了荟萃分析。他们纳入了12项关于BDNF 196 G/A基因多态性的研究和4项关于BDNF 270 C/T基因多态性的研究。荟萃分析显示，在所有研究对象中，PD与BDNF 196 A等位基因之间无关联（比值比[OR]=1.066，95%置信区间[CI][0.972, 1.169]，p = 0.173）。然而，按种族进行的荟萃分析发现，欧洲人中BDNF 196 AA + AG基因型与PD相关，而亚洲人中无此关联（OR = 1.212，95% CI[1.007, 1.458]，p = 0.042；OR = 1.0567，95% CI[0.913, 1.221]，p = 0.465）。荟萃分析显示，PD与BDNF 270 C/T基因多态性之间无关联（T等位基因的OR = 1.213，95% CI[0.923, 1.595]，p = 0.165）。该荟萃分析发现欧洲人中BDNF 196 G/A基因多态性与PD相关，而亚洲人中无此关联，但未发现BDNF 270 C/T基因多态性与PD之间存在关联。
