Gastroenterology Division, King Khalid University Hospital, King Saud University, Riyadh 11461, Saudi Arabia.
World J Gastroenterol. 2013 Apr 21;19(15):2374-8. doi: 10.3748/wjg.v19.i15.2374.
To identify the seroprevalence of celiac disease among healthy Saudi adolescents.
Between December 2007 and January 2008, healthy students from the 10(th) to 12(th) grades were randomly selected from three regions in Saudi Arabia. These regions included the following: (1) Aseer region, with a student population of 25512; (2) Madinah, with a student population of 23852; and (3) Al-Qaseem, with a student population of 16067. Demographic data were recorded, and a venous blood sample (5-10 mL) was taken from each student. The blood samples were tested for immunoglobulin A and immunoglobulin G endomysial antibodies (EMA) by indirect immunofluorescence.
In total, 1167 students (614 males and 553 females) from these three regions were randomly selected. The majority of the study population was classified as lower middle class (82.7%). There were 26 (2.2%) students who had a positive anti-EMA test, including 17 females (3.1%) and 9 males (1.5%). Al-Qaseem region had the highest celiac disease prevalence among the three studied regions in Saudi Arabia (3.1%). The prevalence by region was as follows: Aseer 2.1% (10/479), Madinah 1.8% (8/436), and Al-Qaseem 3.2% (8/252). The prevalence in Madinah was significantly lower than the prevalence in Aseer and Al-Qaseem (P = 0.02).
Our data suggest celiac disease prevalence might be one of the highest in the world. Further studies are needed to determine the real prevalence.
确定沙特健康青少年中乳糜泻的血清流行率。
2007 年 12 月至 2008 年 1 月期间，从沙特阿拉伯的三个地区随机抽取 10 至 12 年级的健康学生。这些地区包括：（1）阿西尔地区，学生人数为 25512 人；（2）麦地那，学生人数为 23852 人；（3）盖西姆，学生人数为 16067 人。记录人口统计学数据，并从每个学生抽取 5-10 毫升静脉血样。用间接免疫荧光法检测免疫球蛋白 A 和免疫球蛋白 G 内肌内膜抗体（EMA）。
共从这三个地区随机抽取了 1167 名学生（614 名男性和 553 名女性）。研究人群的大多数属于中下层阶级（82.7%）。有 26 名（2.2%）学生抗 EMA 检测呈阳性，包括 17 名女性（3.1%）和 9 名男性（1.5%）。沙特阿拉伯的三个研究地区中，Al-Qaseem 地区的乳糜泻患病率最高（3.1%）。按地区划分的患病率如下：阿西尔 2.1%（479/2300），麦地那 1.8%（436/2369），Al-Qaseem 3.2%（252/800）。麦地那的患病率明显低于阿西尔和 Al-Qaseem（P=0.02）。
我们的数据表明，乳糜泻的患病率可能是世界上最高的之一。需要进一步的研究来确定真实的患病率。
