Yoon Henry H, Iacono William G, Malone Stephen M, Bernat Edward M, McGue Matt
University of Minnesota, Twin Cities, 75 East River Road, Minneapolis, MN 55455, United States.
Biol Psychol. 2008 Dec;79(3):329-36. doi: 10.1016/j.biopsycho.2008.08.001. Epub 2008 Aug 13.
The present study examined the degree to which the P300 component of the visual brain event-related potential and associated task performance deficits often observed in children with attention-deficit hyperactivity disorder (ADHD) are attributable to comorbid childhood disruptive disorders using a community sample of 11-year olds from the Minnesota Twin Family Study. Subjects were divided into "ADHD-pure" (ADHD without oppositional defiant disorder, ODD, or conduct disorder, CD), "ADHD-comorbid" (ADHD with ODD or CD), and comparison (no childhood disruptive disorder) groups using DSM-III-R diagnoses. Results showed that ADHD-comorbid but not ADHD-pure subjects displayed significant P3 amplitude reduction and poorer task performance compared to controls. No group effects for P3 latency or reaction time were seen. Although ADHD-comorbid children had marginally more ADHD symptoms compared to ADHD-pure children, this did not account for their reduced P3, suggesting that the observed neurobehavioral deficits reflected the effects of co-occurring childhood disruptive disorders.
本研究利用明尼苏达双生子家庭研究中11岁儿童的社区样本，考察了注意缺陷多动障碍（ADHD）儿童中经常观察到的视觉脑事件相关电位P300成分及相关任务表现缺陷在多大程度上可归因于共病的儿童期破坏性行为障碍。根据《精神疾病诊断与统计手册第三版修订版》（DSM-III-R）的诊断，将受试者分为“单纯ADHD”（无对立违抗障碍、ODD或品行障碍、CD的ADHD）、“共病ADHD”（伴有ODD或CD的ADHD）和对照组（无儿童期破坏性行为障碍）。结果显示，与对照组相比，共病ADHD的受试者而非单纯ADHD的受试者表现出显著的P3波幅降低和较差的任务表现。未观察到P3潜伏期或反应时间的组间效应。尽管与单纯ADHD儿童相比，共病ADHD的儿童ADHD症状略多，但这并不能解释其P3波幅降低的情况，这表明观察到的神经行为缺陷反映了同时存在的儿童期破坏性行为障碍的影响。
