Department of Biological Sciences, Florida International University, 11200 Southwest 8th Street, Miami, FL 33199, United States.
J Nat Prod. 2013 May 24;76(5):965-8. doi: 10.1021/np300822b. Epub 2013 Apr 24.
Aristolochic acid I (AA-I), naturally occurring in Aristolochia plants, is a potent nephrotoxin and carcinogen. Here we report that AA-I suffers hydrogenolysis with loss of the nitro group by reaction with cysteine or glutathione to give aristolic acid. Since the reaction can proceed in aqueous solutions at pH 7.0 and 37 °C, it is inferred that it may also occur in biological systems and contribute to the nephrotoxic effects induced by AA-I.
马兜铃酸 I（AA-I）存在于马兜铃属植物中，是一种强效的肾毒素和致癌物。在这里，我们报告 AA-I 可与半胱氨酸或谷胱甘肽发生氢解反应，硝基基团脱落，生成马兜铃酸。由于该反应可在 pH 值为 7.0 和 37°C 的水溶液中进行，因此可以推断它也可能在生物体系中发生，并导致 AA-I 引起的肾毒性。
