Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida, India.
Curr Drug Targets. 2013 Jun 1;14(6):666-75. doi: 10.2174/1389450111314060008.
Silent information regulator 2 (Sir2) proteins, or sirtuins, are a family of proteins which influence several physiological responses and have implications for treating diseases of ageing. In this context, we have presented a summarized view on the discovery of Sir2 family proteins, the enzymatic activities, the role of sirtuins in aging, lifespan and onset of age-related symptoms. In addition, we have described the roles of mammalian sirtuins-with particular emphasis on their associations to aging, metabolism, and age related diseases with recent references. Current findings provide an understanding about mammalian sirtuins and their target diseases, small molecules discovery or drug discovery targeting sirtuin to tackle the serious diseases of aging.
沉默信息调节因子 2（Sir2）蛋白，也称为沉默调节蛋白，是一类能够影响多种生理反应的蛋白，对治疗与衰老相关的疾病具有重要意义。在此背景下，我们对 Sir2 家族蛋白的发现、酶活性、在衰老、寿命和与年龄相关症状的发生中发挥的作用进行了综述。此外，我们还描述了哺乳动物沉默调节蛋白的作用，特别强调了它们与衰老、代谢和与年龄相关的疾病的关联，并引用了最新的参考文献。目前的研究结果为我们理解哺乳动物沉默调节蛋白及其靶疾病提供了依据，也为发现靶向沉默调节蛋白的小分子或药物以应对严重的衰老相关疾病提供了思路。
