Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Am J Reprod Immunol. 2013 Oct;70(4):327-35. doi: 10.1111/aji.12127. Epub 2013 Apr 25.
Uterine leiomyomata are the most common reproductive tumor in women, and their cause is not known.
Plasma samples from 155 women (74 with and 81 without ultrasound-confirmed leiomyoma) from a new study of leiomyoma risk factors in the Detroit, Michigan area, were examined for any cross-sectional associations between commonly examined cytokines and leiomyoma presence.
Associations varied by season of sample collection defined a priori as winter (December-February) and non-winter seasons. In the winter months, interleukin (IL)13 and IL17 were positively and IP10 was inversely associated with having a leiomyoma. In the non-winter samples, VEGF, G-CSF, and IP10 were positively associated and Monocyte chemotactic protein-1, IL13, and IL17 were inversely associated with having a leiomyoma. Associations were not changed by adjustment for age or BMI.
These data suggest that new insight into leiomyoma formation may be acquired through investigation of the immune system.
子宫肌瘤是女性最常见的生殖系统肿瘤，其病因尚不清楚。
对底特律、密歇根地区子宫肌瘤危险因素新研究中 155 名女性（74 名经超声证实患有子宫肌瘤，81 名未患有子宫肌瘤）的血浆样本进行检测，以研究常见细胞因子与子宫肌瘤存在之间是否存在横断面关联。
关联因样本采集季节而异，预先定义为冬季（12 月至 2 月）和非冬季。在冬季，白细胞介素 (IL)13 和 IL17 与子宫肌瘤的存在呈正相关，而 IP10 则呈负相关。在非冬季样本中，VEGF、G-CSF 和 IP10 与子宫肌瘤的存在呈正相关，单核细胞趋化蛋白-1、IL13 和 IL17 则与子宫肌瘤的存在呈负相关。调整年龄或 BMI 后，这些关联并未改变。
这些数据表明，通过对免疫系统的研究，可能会获得对子宫肌瘤形成的新认识。
