热量限制及其模拟物。
Caloric restriction and its mimetics.
机构信息
Department of Biological Sciences, Inha University, Incheon 402-751, Korea.
出版信息
BMB Rep. 2013 Apr;46(4):181-7. doi: 10.5483/bmbrep.2013.46.4.033.
Abstract
Caloric restriction is the most reliable intervention to prevent age-related disorders and extend lifespan. The reduction of calories by 10-30% compared to an ad libitum diet is known to extend the longevity of various species from yeast to rodents. The underlying mechanisms by which the benefits of caloric restriction occur have not yet been clearly defined. However, many studies are being conducted in an attempt to elucidate these mechanisms, and there are indications that the benefits of caloric restriction are related to alteration of the metabolic rate and the accumulation of reactive oxygen species. During molecular signaling, insulin/insulin-like growth factor signaling, target of rapamycin pathway, adenosine monophosphate activated protein kinase signaling, and Sirtuin are focused as underlying pathways that mediate the benefits of caloric restriction. Here, we will review the current status of caloric restriction.
摘要
热量限制是预防与年龄相关的疾病和延长寿命最可靠的干预措施。与随意饮食相比，减少 10-30%的卡路里摄入量已被证明可以延长从酵母到啮齿动物等各种物种的寿命。目前尚未明确界定热量限制带来益处的潜在机制。然而，许多研究正在进行中，试图阐明这些机制，并且有迹象表明，热量限制的益处与代谢率的改变和活性氧的积累有关。在分子信号转导过程中，胰岛素/胰岛素样生长因子信号、雷帕霉素靶蛋白通路、单磷酸腺苷激活蛋白激酶信号和 Sirtuin 被作为介导热量限制益处的潜在通路进行了重点研究。在这里，我们将综述热量限制的现状。
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