Department of Physiotherapy, São Paulo State University, Presidente Prudente, São Paulo, Brazil.
Respiration. 2013;86(6):479-85. doi: 10.1159/000348398. Epub 2013 Apr 19.
Smoking impairs mucociliary clearance and increases respiratory infection frequency and severity in subjects with and without smoking-related chronic lung diseases.
This study evaluated the effects of smoking intensity on mucociliary clearance in active smokers.
Seventy-five active smokers were grouped into light (1-10 cigarettes/day; n = 14), moderate (11-20 cigarettes/day; n = 34) and heavy smokers (≥21 cigarettes/day; n = 27) before starting a smoking cessation programme. Smoking behaviour, nicotine dependence, pulmonary function, carbon monoxide in exhaled air (exCO), carboxyhaemoglobin (COHb) and mucociliary clearance measured by the saccharin transit time (STT) test were all evaluated. An age-matched non-smoker group (n = 24) was assessed using the same tests.
Moderate (49 ± 7 years) and heavy smokers (46 ± 8 years) had higher STT (p = 0.0001), exCO (p < 0.0001) and COHb (p < 0.0001) levels compared with light smokers (51 ± 15 years) and non-smokers (50 ± 11 years). A positive correlation was observed between STT and exCO (r = 0.4; p < 0.0001), STT and cigarettes/day (r = 0.3, p = 0.02) and exCO and cigarettes/day (r = 0.3, p < 0.01).
Smoking impairs mucociliary clearance and is associated with cigarette smoking intensity.
吸烟会损害黏液纤毛清除功能，并增加有或无吸烟相关慢性肺部疾病的患者发生呼吸道感染的频率和严重程度。
本研究评估吸烟强度对吸烟者黏液纤毛清除功能的影响。
75 名主动吸烟者在开始戒烟计划前分为轻度（每天 1-10 支香烟；n=14）、中度（每天 11-20 支香烟；n=34）和重度（每天≥21 支香烟；n=27）吸烟者。评估吸烟行为、尼古丁依赖、肺功能、呼气一氧化碳（exCO）、碳氧血红蛋白（COHb）以及用糖精通过时间（STT）试验测量的黏液纤毛清除率。还评估了一个年龄匹配的非吸烟者组（n=24），他们使用相同的测试进行评估。
中度（49±7 岁）和重度吸烟者（46±8 岁）的 STT（p=0.0001）、exCO（p<0.0001）和 COHb（p<0.0001）水平均高于轻度吸烟者（51±15 岁）和非吸烟者（50±11 岁）。STT 与 exCO 之间呈正相关（r=0.4；p<0.0001），STT 与吸烟量之间呈正相关（r=0.3，p=0.02），exCO 与吸烟量之间呈正相关（r=0.3，p<0.01）。
吸烟会损害黏液纤毛清除功能，且与吸烟强度有关。
