Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Menopause. 2013 May;20(5):548-53. doi: 10.1097/GME.0b013e318271b1da.
It has been revealed that osteocalcin is a regulator of energy metabolism. We investigated the relationship between serum osteocalcin levels and metabolic syndrome (MetS) in Chinese postmenopausal women.
A total of 1,789 postmenopausal women, aged 41 to 78 years, were selected from four communities in Shanghai, China. Serum levels of osteocalcin were measured with an electrochemiluminescence immunoassay. The diagnostic definition of MetS followed the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.
Serum osteocalcin levels were significantly lower in participants with MetS than in non-MetS participants (median [interquartile range], 18.51 [15.52-23.46] vs. 21.09 [16.98-26.26] ng/mL, P < 0.01). The frequency of MetS and its components decreased with increasing increments of serum osteocalcin levels (all P for trend < 0.05), with the exception of the frequency of low levels of high-density lipoprotein cholesterol. Serum osteocalcin levels significantly decreased with increasing number of metabolic disorders (P for trend < 0.01). Furthermore, binary logistic regression analysis revealed that participants with higher serum osteocalcin levels had lower odds ratios (ORs) for MetS (OR, 0.123; 95% CI, 0.053-0.283), central obesity (OR, 0.134; 95% CI, 0.060-0.299), and hyperglycemia (OR, 0.142; 95% CI, 0.066-0.302).
Serum osteocalcin levels are negatively associated with MetS, particularly central obesity and hyperglycemia, in Chinese postmenopausal women.
研究已经表明骨钙素是能量代谢的调节剂。我们调查了中国绝经后妇女的血清骨钙素水平与代谢综合征（MetS）之间的关系。
从中国上海的四个社区中选择了 1789 名年龄在 41 至 78 岁之间的绝经后妇女。采用电化学发光免疫分析法测定血清骨钙素水平。MetS 的诊断定义遵循 2007 年中国成人血脂异常防治指南。
患有 MetS 的参与者的血清骨钙素水平明显低于非 MetS 参与者（中位数[四分位数间距]，18.51[15.52-23.46] vs. 21.09[16.98-26.26]ng/mL，P<0.01）。随着血清骨钙素水平的升高，MetS 及其各组分的发生频率降低（所有趋势 P<0.05），高密度脂蛋白胆固醇水平较低的情况除外。血清骨钙素水平随着代谢紊乱数量的增加而显著降低（趋势 P<0.01）。此外，二元逻辑回归分析显示，血清骨钙素水平较高的参与者发生 MetS 的比值比（OR）较低（OR，0.123；95%CI，0.053-0.283），中心性肥胖（OR，0.134；95%CI，0.060-0.299）和高血糖（OR，0.142；95%CI，0.066-0.302）。
血清骨钙素水平与中国绝经后妇女的 MetS 呈负相关，尤其是中心性肥胖和高血糖。
