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用于治疗下尿路症状的532纳米180瓦(GreenLight®)前列腺激光汽化术:集成冷却系统的新型侧射光纤的疗效能维持多久?

The 532-nm 180-W (GreenLight®) laser vaporization of the prostate for the treatment of lower urinary tract symptoms: how durable is the new side-fire fiber with integrated cooling system?

作者信息

Brunken Claus, Munsch Maximilian, Tauber Stephan, Schmidt Rainer, Seitz Christian

机构信息

Department of Urology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany,

出版信息

Lasers Med Sci. 2014 May;29(3):1307-12. doi: 10.1007/s10103-013-1320-7. Epub 2013 Apr 25.

DOI:10.1007/s10103-013-1320-7
PMID:23615757
Abstract

The 532-nm side-fire laser vaporization is established for the treatment of symptomatic benign prostate hyperplasia. Meanwhile, the third generation of this system is offered by American Medical Systems, Inc. The laser power increased from 80 and 120 to 180 W from the first to the third generation. Despite good functional results, with the 80- and 120-W systems, the removal of prostate tissue is limited because of fiber degradation. To overcome this problem, the fiber was designed newly with an integrated cooling system and a sensor for decreasing the laser energy in case of overheating. We evaluate whether the new fiber still suffers from degradation with consecutive drop of power transmission during the procedure. The power output of the cooled fiber was measured in vitro and during prostate vaporization in ten patients. Laser beam power was measured at baseline and after the application each of 50 kJ during laser vaporization. Power emission of the fiber remains constant at 20, 80, and 180 W of power settings over the whole 40-kJ lifespan. During the transurethral procedure, a median total energy of 276 kJ (standard deviation 153 kJ) was applied for vaporization. Median power output from the fiber at the end of the procedure was 97% from the baseline value. There were no fiber malfunctions observed. In contrast to former generations, the third-generation laser fiber is durable without significant power loss during prostate vaporization.

摘要

532纳米侧向发射激光汽化术已被确立用于治疗有症状的良性前列腺增生。同时,美国美敦力公司提供该系统的第三代产品。从第一代到第三代,激光功率从80瓦和120瓦增加到了180瓦。尽管功能效果良好,但使用80瓦和120瓦系统时,由于光纤降解,前列腺组织的切除受到限制。为克服这一问题,新设计的光纤带有集成冷却系统和一个在过热时降低激光能量的传感器。我们评估这种新光纤在手术过程中是否仍会因功率传输连续下降而出现降解。在体外以及对10例患者进行前列腺汽化手术时测量了冷却光纤的功率输出。在激光汽化过程中,在基线以及每次施加50千焦能量后测量激光束功率。在整个40千焦的使用寿命期间,光纤在20瓦、80瓦和180瓦功率设置下的功率发射保持恒定。在经尿道手术过程中,汽化的中位总能量为276千焦(标准差153千焦)。手术结束时光纤的中位功率输出为基线值的97%。未观察到光纤故障。与前几代产品相比,第三代激光光纤耐用,在前列腺汽化过程中无明显功率损失。

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Nat Rev Urol. 2014 Mar;11(3):142-52. doi: 10.1038/nrurol.2014.23. Epub 2014 Mar 4.
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