Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.
J Urol. 2011 Feb;185(2):712-8. doi: 10.1016/j.juro.2010.09.076. Epub 2010 Dec 18.
We studied vaporization parameters, and anatomical and histopathological outcomes of photoselective vaporization of the prostate with the novel GreenLight™ XPS™ 180 W, 532 nm lithium triborate laser and MoXy™ fiber in a survival model of living dogs. We compared these findings with those of the existing GreenLight HPS™ 120 W 532 nm lithium triborate laser photoselective vaporization of the prostate in living dogs.
Eight dogs underwent antegrade photoselective vaporization of the prostate with the 180 W laser delivered through a new 750 μm (vs the existing 600 μm core diameter), 50% larger, spot sized, side firing fiber. Four dogs were sacrificed 3 hours and 8 weeks postoperatively, respectively. We recorded laser energy and time. Prostates were sectioned, measured and histologically analyzed after hematoxylin and eosin, triphenyltetrazolium chloride or Gomori trichrome staining and compared with a normal control.
Photoselective vaporization of the prostate with the 180 W laser bloodlessly created a 76% larger cavity (mean 11.8 vs 6.7 cm(3), p = 0.014), vaporized tissue at a 77% higher rate (mean 2.3 vs 1.3 cm(3) per minute, p = 0.03) and did so in 37% less time per volume vaporized (0.5 vs 0.8 minutes per cm(3), p = 0.003). Hematoxylin and eosin, and triphenyltetrazolium chloride staining histologically revealed a 33% thicker mean coagulation zone vs that of 120 W laser photoselective vaporization of the prostate (2.0 ± 0.4 vs 1.5 ± 0.3 mm, p <0.005). In prostates healed for 8 weeks postoperatively hematoxylin and eosin, and Gomori trichrome staining showed re-epithelialized cavities with negligible submucosal fibrosis compared with a normal prostate.
GreenLight XPS 180 W 532 nm lithium triborate laser photoselective vaporization of the prostate with the MoXy fiber has a significantly higher vaporization rate and speed with a deeper hemostatic coagulation zone but favorable tissue interaction and healing equal to those of HPS 120 W laser photoselective vaporization of the prostate in dogs.
我们研究了新型 GreenLight XPS 180 W，532nm 硼酸锂二硼酸盐激光和 MoXy 光纤在活体犬前列腺光选择性汽化中的汽化参数以及解剖和组织病理学结果。我们将这些结果与活体犬中现有的 GreenLight HPS 120 W 532nm 硼酸锂二硼酸盐激光前列腺光选择性汽化的结果进行了比较。
8 只狗接受了 180 W 激光的顺行光选择性前列腺汽化，激光通过一种新的 750μm（与现有的 600μm 芯径相比），50%更大，点状，侧面发射纤维传递。分别在术后 3 小时和 8 周处死 4 只狗。我们记录了激光能量和时间。前列腺在苏木精和伊红，三苯基氯化四氮唑或 Gomori 三色染色后被切片，测量和组织学分析，并与正常对照进行比较。
180 W 激光的光选择性前列腺汽化术无血地创建了一个大 76％的腔（平均 11.8 比 6.7cm3，p=0.014），以 77％的更高速度汽化组织（平均 2.3 比 1.3cm3每分钟，p=0.03），并且每汽化体积所需的时间减少了 37％（0.5 比 0.8 分钟每 cm3，p=0.003）。苏木精和伊红以及三苯基氯化四氮唑染色组织学显示，与 120 W 激光前列腺光选择性汽化术相比，平均凝固带厚 33％（2.0 ± 0.4 比 1.5 ± 0.3mm，p <0.005）。在术后 8 周愈合的前列腺中，苏木精和伊红以及 Gomori 三色染色显示与正常前列腺相比，腔被重新上皮化，粘膜下纤维化可忽略不计。
GreenLight XPS 180 W 532nm 硼酸锂二硼酸盐激光和 MoXy 光纤的前列腺光选择性汽化具有更高的汽化率和速度，具有更深的止血凝固区，但与狗的 HPS 120 W 激光前列腺光选择性汽化术相比，具有相似的组织相互作用和愈合效果。
