Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Vet Res. 2013 Apr 24;44(1):27. doi: 10.1186/1297-9716-44-27.
Flavobacterium columnare (F. columnare) is the causative agent of columnaris disease. This bacterium affects both cultured and wild freshwater fish including many susceptible commercially important fish species. F. columnare infections may result in skin lesions, fin erosion and gill necrosis, with a high degree of mortality, leading to severe economic losses. Especially in the last decade, various research groups have performed studies aimed at elucidating the pathogenesis of columnaris disease, leading to significant progress in defining the complex interactions between the organism and its host. Despite these efforts, the pathogenesis of columnaris disease hitherto largely remains unclear, compromising the further development of efficient curative and preventive measures to combat this disease. Besides elaborating on the agent and the disease it causes, this review aims to summarize these pathogenesis data emphasizing the areas meriting further investigation.
黄杆菌（F. columnare）是柱状病的病原体。这种细菌会感染养殖和野生淡水鱼，包括许多易受感染的商业重要鱼类品种。F. columnare 感染可能导致皮肤损伤、鳍侵蚀和鳃坏死，死亡率很高，导致严重的经济损失。特别是在过去十年中，各个研究小组进行了旨在阐明柱状病发病机制的研究，在确定该生物体与其宿主之间的复杂相互作用方面取得了重大进展。尽管做出了这些努力，但柱状病的发病机制迄今在很大程度上仍不清楚，这影响了针对这种疾病的有效治疗和预防措施的进一步发展。除了阐述病原体及其引起的疾病外，本综述旨在总结这些发病机制数据，强调值得进一步研究的领域。
