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简要报告:自闭症谱系障碍中的沟通障碍性质是否与父母的广泛自闭症表型有关?

Brief report: do the nature of communication impairments in autism spectrum disorders relate to the broader autism phenotype in parents?

机构信息

Neurocognitive Developmental Unit, School of Psychology, University of Western Australia, M304, 35 Stirling Highway, Crawley, WA, 6009, Australia,

出版信息

J Autism Dev Disord. 2013 Dec;43(12):2984-9. doi: 10.1007/s10803-013-1838-3.

Abstract

Extensive empirical evidence indicates that the lesser variant of Autism Spectrum Disorders (ASD) involves a communication impairment that is similar to, but milder than, the deficit in clinical ASD. This research explored the relationship between the broader autism phenotype (BAP) among parents, an index of genetic liability for ASD, and proband communication difficulties. ASD probands with at least one BAP parent (identified using the Autism Spectrum Quotient) had greater structural and pragmatic language difficulties (assessed using the Children's Communication Checklist-2) than ASD probands with no BAP parent. This finding provides support for the position that genetic liability for ASD is associated with increased communication difficulties across structural and pragmatic domains.

摘要

大量经验证据表明,自闭症谱系障碍(ASD)的轻度变体涉及沟通障碍,与临床 ASD 的缺陷相似,但程度较轻。这项研究探讨了父母的广泛自闭症表型(BAP)与 ASD 遗传易感性指标以及先证者沟通困难之间的关系。使用自闭症谱系商数(Autism Spectrum Quotient)确定的至少有一位 BAP 父母的 ASD 先证者,其结构和语用语言困难程度(使用儿童沟通检查表-2评估)大于没有 BAP 父母的 ASD 先证者。这一发现支持了这样的观点,即 ASD 的遗传易感性与结构和语用领域的沟通困难增加有关。

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