Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8017, USA.
Curr Opin Immunol. 2013 Jun;25(3):300-6. doi: 10.1016/j.coi.2013.03.010. Epub 2013 Apr 24.
Regulated actin dynamics play a central role in modulating signaling events at the immunological synapse (IS). Polymerization of actin filaments at the periphery of the IS, coupled to depolymerization near the center, generates a centripetal flow of the actin network and associated movement of signaling molecules. A recent flurry of papers addresses the role of myosin II in facilitating these events. Investigators agree that myosin II is present at the IS, where it forms actomyosin arcs within the peripheral supramolecular activation cluster, a region corresponding to the lamellum of migrating cells. However, there is substantial disagreement about the extent to which myosin II drives IS formation and signaling events leading to T cell activation.
规管肌动蛋白动力学在调节免疫突触 (IS) 中的信号事件中起着核心作用。IS 周边的肌动蛋白丝聚合，与中心附近的解聚相结合，产生肌动蛋白网络向心流动和相关信号分子的运动。最近有大量论文探讨了肌球蛋白 II 在促进这些事件中的作用。研究人员一致认为，肌球蛋白 II 存在于 IS 中，在那里它在周边超分子激活簇内形成肌球蛋白-肌动蛋白弧，这一区域对应于迁移细胞的片层。然而，对于肌球蛋白 II 在多大程度上驱动 IS 的形成以及导致 T 细胞激活的信号事件，存在着很大的分歧。
