Du Jing, Fang Chunju, Mao Ye, Zhao Jian, Tie Yan, Xiang Zhongzheng
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu, China.
Collaborative Innovation Center of Biotherapy Chengdu, China.
Int J Clin Exp Pathol. 2018 Jan 1;11(1):375-381. eCollection 2018.
Many studies have analyzed the association between between glutathione S-transferase M1 (GSTM1) polymorphism and esophageal cancer, however, the results are inconsistent. This meta-analysis updated and reevaluated the possible associations between GSTM1 polymorphism and susceptibility to esophageal cancer based on Chinese individuals. The PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure and Chinese Biology Medicine were searched up to February 2017. A total of 20 case-control studies including 2113 esophageal cancer cases and 2848 relevant controls were screened out. Overall, the meta-analysis demonstrated significant associations between the GSTM1 null genotype and increased risk for esophageal cancer in the Chinese population. In subgroup analyses, it indicated the similar results in population-based and hospital-based studies, as well as in North China and South China. As for subgroup analysis by histological type, a non-significant association was found in esophageal squamous cell carcinoma. Our study suggested that GSTM1 null genotype might contribute to increased risk of esophageal cancer in Chinese population.
许多研究分析了谷胱甘肽S-转移酶M1（GSTM1）基因多态性与食管癌之间的关联，然而，结果并不一致。这项荟萃分析基于中国人群更新并重新评估了GSTM1基因多态性与食管癌易感性之间的可能关联。检索了截至2017年2月的PubMed、Springer Link、Ovid、中国万方数据知识服务平台、中国知网和中国生物医学数据库。共筛选出20项病例对照研究，包括2113例食管癌病例和2848例相关对照。总体而言，荟萃分析表明GSTM1基因缺失型与中国人群食管癌风险增加之间存在显著关联。在亚组分析中，基于人群和基于医院的研究以及中国北方和南方的研究结果相似。至于按组织学类型进行的亚组分析，在食管鳞状细胞癌中未发现显著关联。我们的研究表明，GSTM1基因缺失型可能会增加中国人群患食管癌的风险。
