Internal Medicine Laboratory, Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Distrito Rubiao Jr. s/n, 18618-970 Botucatu, SP, Brazil.
Br J Nutr. 2013 Nov;110(10):1803-9. doi: 10.1017/S0007114513001256. Epub 2013 May 1.
Obesity is characterised by chronic low-grade inflammation, and lycopene has been reported to display anti-inflammatory effects. However, it is not clear whether lycopene supplementation modulates adipokine levels in vivo in obesity. To determine whether lycopene supplementation can regulate adipokine expression in obesity, male Wistar rats were randomly assigned to receive a control diet (C, n 6) ora hyperenergetic diet (DIO, n 12) for 6 weeks. After this period, the DIO animals were randomised into two groups: DIO (n 6) and DIO supplemented with lycopene (DIO + L, n 6). The animals received maize oil (C and DIO) or lycopene (DIO + L, 10 mg/kg body weight(BW) per d) by oral administration for a 6-week period. The animals were then killed by decapitation, and blood samples and epididymal adipose tissue were collected for hormonal determination and gene expression evaluation (IL-6, monocyte chemoattractant protein-1(MCP-1), TNF-α, leptin and resistin). There was no detectable lycopene in the plasma of the C and DIO groups. However, the mean lycopene plasma concentration was 24 nmol in the DIO + L group. Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and IL-6 gene expression in epididymal adipose tissue and plasma concentrations. Also, it significantly reduced the gene expression of MCP-1 in epididymal adipose tissue. Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels. These data suggest that lycopene may be an effective strategy in reducing inflammation in obesity.
肥胖的特征是慢性低度炎症，番茄红素已被报道具有抗炎作用。然而，目前尚不清楚番茄红素补充剂是否能调节肥胖症患者体内的脂肪因子水平。为了确定番茄红素补充剂是否能调节肥胖症患者的脂肪因子表达，雄性 Wistar 大鼠被随机分为对照组（C，n=6）或高热量饮食组（DIO，n=12），分别喂养 6 周。在这段时间后，DIO 组动物被随机分为两组：DIO（n=6）和 DIO 补充番茄红素（DIO+L，n=6）。动物通过口服给予玉米油（C 和 DIO）或番茄红素（DIO+L，10mg/kg 体重/d），持续 6 周。然后，动物通过断头处死，采集血液样本和附睾脂肪组织，用于激素测定和基因表达评估（IL-6、单核细胞趋化蛋白-1（MCP-1）、TNF-α、瘦素和抵抗素）。C 组和 DIO 组的血浆中均未检测到番茄红素。然而，DIO+L 组的平均番茄红素血浆浓度为 24nmol。尽管番茄红素补充剂并未影响体重或肥胖程度，但它显著降低了附睾脂肪组织和血浆中瘦素、抵抗素和 IL-6 的基因表达。此外，它还显著降低了附睾脂肪组织中 MCP-1 的基因表达。番茄红素通过降低瘦素、抵抗素和血浆 IL-6 水平来影响脂肪因子。这些数据表明，番茄红素可能是减少肥胖症炎症的有效策略。
