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类胡萝卜素负载明胶纳米粒对 Wistar 大鼠血浆细胞因子和脂肪细胞肥大的影响。

Efficacy of Carotenoid-Loaded Gelatin Nanoparticles in Reducing Plasma Cytokines and Adipocyte Hypertrophy in Wistar Rats.

机构信息

Biochemistry and Molecular Biology Postgraduate Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.

Nutrition Course, Potiguar University, Natal 59056-000, Brazil.

出版信息

Int J Mol Sci. 2023 Jun 26;24(13):10657. doi: 10.3390/ijms241310657.

DOI:10.3390/ijms241310657
PMID:37445834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10341683/
Abstract

The present study investigated the effect of gelatin-based nanoparticles (EPG) loaded with a carotenoid-rich crude extract (CE) on systemic and adipose tissue inflammatory response in a model with inflammation induced by a high glycemic index and high glycemic load diet (HGLI). Nanoparticles synthesized were characterized by different physical and chemical methods. The in vivo investigation evaluated Wistar rats (n = 20, 11 days, adult male with 21 weeks) subdivided into untreated (HGLI diet), conventional treatment (nutritionally adequate diet), treatment 1 (HGLI + crude extract (12.5 mg/kg)), and treatment 2 (HGLI + EPG (50 mg/kg)) groups. Dietary intake, caloric intake and efficiency, weight, inflammatory cytokines tissue concentration, visceral adipose tissue (VAT) weight, histopathological analysis, and antioxidant activity in plasma and VAT were investigated. EPG showed the same physical and chemical characteristics as previous batches (95.2 nm, smooth surface, and chemical interactions between materials). The EPG-treated group was the only group promoting negative ∆dietary intake, ∆caloric efficiency, and ∆weight. In addition, it presented a significant reduction ( < 0.05) in IL-6 and leptin levels and a greater presence of multilocular adipocytes. The results suggest that EPG can act as a nutraceutical in adjuvant therapy for treating inflammatory diseases associated with adipose tissue accumulation.

摘要

本研究调查了基于明胶的纳米粒子（EPG）负载富含类胡萝卜素的粗提物（CE）对高血糖指数和高血糖负荷饮食（HGLI）诱导的炎症模型中系统性和脂肪组织炎症反应的影响。通过不同的物理和化学方法对合成的纳米粒子进行了表征。体内研究评估了 Wistar 大鼠（n = 20，11 天，成年雄性，21 周），分为未处理组（HGLI 饮食）、常规治疗组（营养充足饮食）、治疗 1 组（HGLI +粗提物（12.5mg/kg））和治疗 2 组（HGLI + EPG（50mg/kg））。研究了饮食摄入、热量摄入和效率、体重、组织中炎症细胞因子浓度、内脏脂肪组织（VAT）重量、组织病理学分析和血浆及 VAT 中的抗氧化活性。EPG 表现出与以前批次相同的物理和化学特性（95.2nm，光滑表面，以及材料之间的化学相互作用）。只有 EPG 治疗组促进了负的 ∆饮食摄入、∆热量效率和∆体重。此外，它还显著降低了 IL-6 和瘦素水平，并增加了多房脂肪细胞的存在。结果表明，EPG 可作为治疗与脂肪组织积累相关的炎症性疾病的辅助治疗的营养保健品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ba8/10341683/6af911f121b0/ijms-24-10657-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ba8/10341683/43f1e3e136e3/ijms-24-10657-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ba8/10341683/4faeed410b22/ijms-24-10657-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ba8/10341683/19b34a867eaf/ijms-24-10657-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ba8/10341683/6af911f121b0/ijms-24-10657-g009.jpg

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