Genetic Epidemiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Sleep. 2013 May 1;36(5):671-9. doi: 10.5665/sleep.2624.
Recent studies have suggested that nonrestorative sleep (NRS) symptoms may be distinct from nocturnal insomnia symptoms (NIS). However, there is limited information on the demographic, medical, and biologic correlates of NRS independent from NIS in the general population. This report presents the sociodemographic correlates, patterns of comorbidity with other sleep and physical disorders, C-reactive protein (CRP) levels, and general productivity associated with NIS and NRS in a nationally representative sample of US adults.
National Health and Nutrition Examination Survey (NHANES).
The 2005-2008 surveys of the general population in the United States.
There were 10,908 individuals (20 years or older).
N/A.
Respondents were classified by the presence or absence of NIS and NRS. Compared with those without insomnia symptoms, respondents with NIS were older and had lower family income and educational levels than those with NRS. In addition, there was a significant association between NIS and cardiovascular disease, whereas NRS was associated with other primary sleep disorders (including habitual snoring, sleep apnea, and restless legs syndrome), respiratory diseases (emphysema and chronic bronchitis), thyroid disease, and cancer as well as increased CRP levels. In addition, the study participants with NRS only reported poorer scores on the Functional Outcomes of Sleep Questionnaire (FOSQ) than those without insomnia symptoms or those with NIS only.
These findings suggest that there are substantial differences between NIS and NRS in terms of sociodemographic factors, comorbidity with other sleep and physical disorders, increased CRP level, and functional impairment. An inflammatory response might play a unique role in the pathogenesis of NRS.
最近的研究表明，非恢复性睡眠（NRS）症状可能与夜间失眠症状（NIS）不同。然而，在普通人群中，关于 NRS 与 NIS 无关的人口统计学、医学和生物学相关性的信息有限。本报告介绍了美国成年人全国代表性样本中与 NIS 和 NRS 相关的社会人口统计学相关性、与其他睡眠和身体障碍共病的模式、C 反应蛋白（CRP）水平以及一般生产力。
国家健康和营养检查调查（NHANES）。
美国普通人群 2005-2008 年的调查。
共有 10908 人（20 岁或以上）。
无。
受访者根据是否存在 NIS 和 NRS 进行分类。与没有失眠症状的人相比，NIS 患者年龄较大，家庭收入和教育水平较低。此外，NIS 与心血管疾病显著相关，而 NRS 与其他原发性睡眠障碍（包括习惯性打鼾、睡眠呼吸暂停和不宁腿综合征）、呼吸疾病（肺气肿和慢性支气管炎）、甲状腺疾病和癌症以及 CRP 水平升高有关。此外，仅患有 NRS 的研究参与者在睡眠功能结果问卷（FOSQ）上的评分比没有失眠症状或只有 NIS 的参与者差。
这些发现表明，在社会人口统计学因素、与其他睡眠和身体障碍共病、CRP 水平升高和功能障碍方面，NIS 和 NRS 之间存在显著差异。炎症反应可能在 NRS 的发病机制中发挥独特作用。
