Walsh L J, Davis M F, Xu L J, Savage N W
Department of Dentistry, University of Queensland, Brisbane, Australia.
J Oral Pathol Med. 1995 Jul;24(6):266-72. doi: 10.1111/j.1600-0714.1995.tb01180.x.
Mast cells are granule-containing secretory cells which are distributed preferentially about the microvascular bed in oral mucosa. This work examined the contribution of mast cell mediators to inflammation in the oral cavity. Mast cells in oral tissues expressed the serine proteases, tryptase and chymase, with a minor subpopulation being chymase-negative. Mast cells contained the cytokine tumour necrosis factor-alpha (TNF) in their granules. Degranulation of mast cells was a consistent feature of inflammatory lesions (lichen planus, gingivitis, pulpitis, periapical inflammation). In lichen planus, intracellular stores of TNF were depleted, and expression of mRNA for TNF was upregulated, indicating ongoing production and release of the cytokine. The density of mast cells in tissue compartments was related to the level of expression of E-selectin, an endothelial adhesion molecule which is known to be induced in skin by TNF derived from degranulating mast cells. Further attention should be directed toward the role of mast cell products, particularly TNF, in inflammation in the oral cavity.
肥大细胞是含有颗粒的分泌细胞，优先分布于口腔黏膜的微血管床周围。这项研究探讨了肥大细胞介质在口腔炎症中的作用。口腔组织中的肥大细胞表达丝氨酸蛋白酶、类胰蛋白酶和糜蛋白酶，其中一小部分亚群为糜蛋白酶阴性。肥大细胞的颗粒中含有细胞因子肿瘤坏死因子-α（TNF）。肥大细胞脱颗粒是炎症病变（扁平苔藓、牙龈炎、牙髓炎、根尖周炎）的一个常见特征。在扁平苔藓中，TNF的细胞内储存被耗尽，TNF的mRNA表达上调，表明该细胞因子正在持续产生和释放。组织隔室中肥大细胞的密度与E-选择素的表达水平相关，E-选择素是一种内皮黏附分子，已知在皮肤中可由脱颗粒肥大细胞产生的TNF诱导。应进一步关注肥大细胞产物，尤其是TNF，在口腔炎症中的作用。
