Saxena S, Wong E T
Department of Laboratories and Pathology, Los Angeles County-University of Southern California Medical Center.
Arch Pathol Lab Med. 1990 Jul;114(7):715-9.
This study was performed to determine whether hematologic indexes might show heterogeneity among different subgroups of the population and, if differences were found, to develop reference ranges for each subgroup. Complete blood cell counts and leukocyte differential cell counts were compared in healthy white (n = 663), black (n = 697), Latin-American (n = 535), and Asian (n = 247) adults. Women had significantly lower red blood cell counts, hemoglobin levels, and hematocrits than men. In addition, women in at least three racial/ethnic groups, had higher platelet, white blood cell, and granulocyte counts and lower monocyte counts than men. Among blacks and Latin Americans, women had lower mean corpuscular volumes, mean corpuscular hemoglobin levels, and mean corpuscular hemoglobin concentrations than men. The following racial/ethnic differences were found: higher red blood cell distribution widths and lymphocyte and monocyte counts, and lower hemoglobin levels, hematocrits, mean corpuscular hemoglobin levels, mean corpuscular hemoglobin concentrations, and white blood cell, granulocyte, and band counts among blacks; higher white blood cell, granulocyte, and band counts among Latin Americans; and higher red blood cell and lower lymphocyte and monocyte counts among Asians than one or more of the other three groups. We concluded that the complete blood cell counts and leukocyte differential cell counts exhibit marked heterogeneity and that reference ranges that reflect the proper racial, ethnic, and sex group should be developed for these parameters.
本研究旨在确定血液学指标在不同人群亚组中是否存在异质性，若发现差异，则为每个亚组制定参考范围。对健康的白人（n = 663）、黑人（n = 697）、拉丁裔（n = 535）和亚洲人（n = 247）成年人进行了全血细胞计数和白细胞分类计数比较。女性的红细胞计数、血红蛋白水平和血细胞比容显著低于男性。此外，至少在三个种族/族裔群体中，女性的血小板、白细胞和粒细胞计数高于男性，单核细胞计数低于男性。在黑人和拉丁裔中，女性的平均红细胞体积、平均红细胞血红蛋白水平和平均红细胞血红蛋白浓度低于男性。发现了以下种族/族裔差异：黑人的红细胞分布宽度、淋巴细胞和单核细胞计数较高，而血红蛋白水平、血细胞比容、平均红细胞血红蛋白水平、平均红细胞血红蛋白浓度以及白细胞、粒细胞和杆状核细胞计数较低；拉丁裔的白细胞、粒细胞和杆状核细胞计数较高；亚洲人的红细胞计数较高，淋巴细胞和单核细胞计数低于其他三个群体中的一个或多个群体。我们得出结论，全血细胞计数和白细胞分类计数存在显著异质性，应为这些参数制定反映适当种族、族裔和性别的参考范围。
