Wang Fan, Fu Shu-Na, Bao Yi-Xuan, Yang Yu, Shen Hui-Fang, Lin Bi-Run, Zhou Guang-Xiong
a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
b Key Laboratory of New Technique for Plant Protection in Guangdong , Institute of Plant Protection, Guangdong Academy of Agricultural Sciences , Guangzhou , China.
Nat Prod Res. 2017 Aug;31(15):1819-1824. doi: 10.1080/14786419.2017.1295240. Epub 2017 Feb 28.
An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with kitamycin A (2), kitamycin B (3), urauchmycin B (4), deisovaleryblastomycin (5) was isolated from a cultured broth of strain 200-09. The structure of the new compound was determined by spectroscopic data, including HR-ESI-MS and NMR. All the compounds exhibited antifungal activities against Candida albicans with MIC of about 25.0 μg mL.
从美国夏威夷海岸采集的土壤样本中分离出的一株放线菌菌株200 - 09，根据其形态、生理和生化特征以及16S rDNA分析，被鉴定为抗生链霉菌。从菌株200 - 09的培养液中分离出一种新的抗霉素类抗生素奇卡霉素C（1），以及奇卡霉素A（2）、奇卡霉素B（3）、浦上霉素B（4）、去异戊酰母霉素（5）。通过高分辨电喷雾电离质谱（HR - ESI - MS）和核磁共振（NMR）等光谱数据确定了新化合物的结构。所有化合物对白色念珠菌均表现出抗真菌活性，最低抑菌浓度（MIC）约为25.0 μg/mL。
