Parks R C, Jacobs B B
J Natl Cancer Inst. 1975 May;54(5):1079-83. doi: 10.1093/jnci/54.5.1079.
The strain-specific BALB/c tumor C4092 was conditioned to grow in H-2 incompatible DBA/1 mice by prior maintenance in vitro as an organ culture explant. It then was serially transplantable in DBA/1 mice and regained its specificity with one passage in BALB/c mice. Changes in transplantation behavior were similar in vivo if the recipients were conditioned by neonatal thymectomy, immunologic enhancement, rabbit antimous serum treatment, or immunization with mitomycin C-inactivated C4092 tumor cells. In vivo- and in vitro-modified tumors differed in degree of transplantability and in the stability of immunogenic changes. However, because of conspicuous similarities in the behavior of these lines, it was concluded that ADAPTations of both host and graft ultimately contribute to graft survival.
通过先前作为器官培养外植体在体外培养，使品系特异性的BALB/c肿瘤C4092适应于在H-2不相容的DBA/1小鼠中生长。然后它可在DBA/1小鼠中连续传代，并在BALB/c小鼠中传代一次后恢复其特异性。如果受体通过新生期胸腺切除、免疫增强、兔抗小鼠血清处理或用丝裂霉素C灭活的C4092肿瘤细胞免疫来进行预处理，移植行为在体内的变化是相似的。体内和体外修饰的肿瘤在移植性程度和免疫原性变化的稳定性方面有所不同。然而，由于这些品系行为上的明显相似性，得出的结论是宿主和移植物的适应性最终都有助于移植物的存活。
