Department of General Practice, University of Melbourne, Australia.
Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(2):376-9. doi: 10.1016/j.ejogrb.2013.03.030. Epub 2013 Apr 29.
Asymptomatic vaginal colonization with Candida species is a known risk factor for vulvovaginal candidiasis (VVC). Taking known risk factors for symptomatic VVC, the authors sought to identify factors associated with asymptomatic colonization.
As part of a randomized controlled trial which compared vaginal candidal colony counts in women taking garlic tablets or placebo, 192 asymptomatic women collected a baseline screening swab for Candida species. Eligibility for this study included at least one self-reported episode of VVC in the previous 12 months and age 18-50 years. Known risk factors for VVC were compared in women colonized with candida and those without colonization.
37% of asymptomatic women who self-reported VVC in the previous 12 months were colonized with vaginal Candida species. Using multivariate analysis, two factors were associated with asymptomatic colonization: a current sexual partner (P=0.02) and being born outside of Australia (P=0.05). Use of oral contraceptives was not statistically significant (P=0.27).
Clinical relevance of asymptomatic colonization with vaginal yeast and its link to episodes of VVC warrants further investigation.
无症状的阴道假丝酵母菌定植是外阴阴道假丝酵母菌病（VVC）的已知危险因素。考虑到 VVC 的已知危险因素，作者试图确定与无症状定植相关的因素。
作为一项比较服用大蒜片和安慰剂的女性阴道假丝酵母菌菌落计数的随机对照试验的一部分，192 名无症状女性采集了基线筛查拭子以检测假丝酵母菌。本研究的入选标准包括过去 12 个月内至少有一次 VVC 的自我报告病史和年龄在 18-50 岁之间。将患有和未患有假丝酵母菌定植的 VVC 女性的已知危险因素进行了比较。
在过去 12 个月内自我报告 VVC 的无症状女性中，有 37%定植了阴道假丝酵母菌。多因素分析显示，两个因素与无症状定植相关：当前的性伴侣（P=0.02）和出生于澳大利亚境外（P=0.05）。口服避孕药的使用无统计学意义（P=0.27）。
阴道酵母无症状定植及其与 VVC 发作的关联的临床意义值得进一步研究。
