用于药物发现的亚硫酸锌试剂的制备和纯化。
Preparation and purification of zinc sulfinate reagents for drug discovery.
机构信息
Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
出版信息
Nat Protoc. 2013 Jun;8(6):1042-7. doi: 10.1038/nprot.2013.059. Epub 2013 May 2.
Abstract
The present protocol details the synthesis of zinc bis(alkanesulfinate)s that can be used as general reagents for the formation of radical species. The zinc sulfinates described herein are generated from the corresponding sulfonyl chlorides by treatment with zinc dust. The products may be used crude, or a simple purification procedure may be performed to minimize incorporation of water and zinc chloride. Although the synthesis of the zinc sulfinate salts can generally be completed within 3 h, workup can take up to 24 h and purification can take up to 3 h. Following the steps in this protocol would enable the user to generate a small toolkit of zinc sulfinate reagents over the course of 1 week.
摘要
本方案详细介绍了锌双（烷基亚磺酸盐）的合成方法，这些化合物可用作形成自由基的通用试剂。本文所述的锌亚磺酸盐是通过用锌粉处理相应的磺酰氯来生成的。这些产物可以不经纯化直接使用，或者可以进行简单的纯化步骤以尽量减少水和氯化锌的混入。虽然锌亚磺酸盐盐的合成通常可以在 3 小时内完成，但后处理可能需要长达 24 小时，而纯化可能需要长达 3 小时。按照本方案中的步骤，用户可以在 1 周的时间内生成一组小型的锌亚磺酸盐试剂。
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