来自红树林内生真菌青霉属ZJ-SY₂的具有免疫抑制活性的聚酮化合物。
Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂.
作者信息
Liu Hongju, Chen Senhua, Liu Weiyang, Liu Yayue, Huang Xishan, She Zhigang
机构信息
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
出版信息
Mar Drugs. 2016 Nov 25;14(12):217. doi: 10.3390/md14120217.
Nine polyketides, including two new benzophenone derivatives, peniphenone () and methyl peniphenone (), along with seven known xanthones (-) were obtained from mangrove endophytic fungus sp. ZJ-SY₂ isolated from the leaves of . Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds , , , and showed potent immunosuppressive activity with IC values ranging from 5.9 to 9.3 μg/mL.
从采自海漆叶片的红树林内生真菌ZJ-SY₂中获得了9种聚酮化合物，包括2种新的二苯甲酮衍生物，即苯甲酮（）和甲基苯甲酮（），以及7种已知的呫吨酮（-）。根据质谱、一维和二维核磁共振数据阐明了它们的结构。化合物、、、和表现出较强的免疫抑制活性，IC值范围为5.9至9.3μg/mL。
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