刺激脑桥被盖脚核可能通过黑皮质素能信号影响肾功能。

Stimulation of the pedunculopontine tegmental nucleus may affect renal function by melanocortinergic signaling.

机构信息

Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.

出版信息

Med Hypotheses. 2013 Jul;81(1):114-6. doi: 10.1016/j.mehy.2013.03.045. Epub 2013 May 1.

DOI:10.1016/j.mehy.2013.03.045

PMID:23642396

Abstract

Deep brain stimulation of the pedunculopontine tegmental nucleus (PPTg) has been reported to improve gait disturbance in animal models of Parkinsonism and among patients with Parkinson's disease. Evidence suggests that neurons in the PPTg are involved in the control of the sympathetic outflow to the kidneys, and sympathetic regulation is a major component of central melanocortin action. Our recent studies using transneuronal labeling pseudorabies virus (PRV)-614 and melanocortin-4 receptor (MC4R)-green fluorescent protein (GFP) transgenic mice supported the melanocortinergic nature of the middle and caudal PPTg (mPPTg and cPPTg). Because PRV-614/MC4R-GFP double-labeled neurons in the mPPTg and cPPTg were detected, we propose a hypothesis that deep brain stimulation of the PPTg may influence renal function by the melanocortinergic pathway.

摘要

已报道脑深部电刺激（DBS）苍白球腹侧部（PPN）核可改善帕金森病动物模型和帕金森病患者的步态障碍。有证据表明，PPN 核中的神经元参与了肾脏交感传出的控制，而交感调节是中枢黑皮质素作用的主要组成部分。我们最近使用跨神经元标记单纯疱疹病毒（PRV）-614 和黑皮质素-4 受体（MC4R）-绿色荧光蛋白（GFP）转基因小鼠的研究支持了中脑和尾状核 PPTg（mPPTg 和 cPPTg）的黑皮质素能性质。由于在 mPPTg 和 cPPTg 中检测到 PRV-614/MC4R-GFP 双标记神经元，我们提出了一个假设，即 DBS 苍白球腹侧部可能通过黑皮质素能途径影响肾功能。