Ghent University, Faculty of Bioscience Engineering, Laboratory of Environmental Toxicology and Aquatic Ecology, J. Plateaustraat 22, B-9000 Ghent, Belgium.
Mar Pollut Bull. 2013 Jun 15;71(1-2):41-50. doi: 10.1016/j.marpolbul.2013.03.039. Epub 2013 Apr 30.
Knowledge on the effects of pharmaceuticals on aquatic marine ecosystems is limited. The aim of this study was therefore to establish the effect thresholds of pharmaceutical compounds occurring in the Belgian marine environment for the marine diatom Phaeodactylum tricornutum, and subsequently perform an environmental risk assessment for these substances. Additionally, a screening-level risk assessment was performed for the pharmaceutical mixtures. No immediate risk for acute toxic effects of these compounds on P. tricornutum were apparent at the concentrations observed in the Belgian marine environment. In two Belgian coastal harbours however, a potential chronic risk was observed for the β-blocker propranolol. No additional risks arising from the exposure to mixtures of pharmaceuticals present in the sampling area could be detected. However, as risk characterization ratios for mixtures of up to 0.5 were observed, mixture effects could emerge should more compounds be taken into account.
关于药物对海洋水生生态系统影响的知识有限。因此，本研究旨在确定在比利时海洋环境中存在的药物化合物对海洋硅藻三角褐指藻的影响阈值，然后对这些物质进行环境风险评估。此外，还对药物混合物进行了筛选水平的风险评估。在比利时海洋环境中观察到的浓度下，这些化合物对三角褐指藻没有明显的急性毒性影响的即时风险。然而，在两个比利时沿海港口，β受体阻滞剂普萘洛尔存在潜在的慢性风险。在采样区域中存在的药物混合物暴露情况下，没有发现其他风险。然而，由于观察到混合物的风险特征比高达 0.5，因此如果考虑更多的化合物，可能会出现混合物的影响。
