University of Medicine and Dentistry of New Jersey/School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, and Cooper Medical School of Rowan University, Camden, NJ, USA.
Neuropsychiatr Dis Treat. 2013;9:567-73. doi: 10.2147/NDT.S44282. Epub 2013 Apr 26.
There is controversy about depression being a physical illness, in part because a reproducible, sensitive, and specific biologic marker is not available. However, there is evidence that mitochondrial dysfunction and oxidative stress may be associated with abnormal brain function and mood disorders, such as depression. This paper reviews selected human and animal studies providing evidence that intracellular mitochondrial metabolic dysfunction in specific brain regions is associated with major depressive disorder. This supports the hypothesis that chronic mitochondrial dysfunction in specific tissues may be associated with depression. Evaluation of mitochondrial dysfunction in specific tissues may broaden the perspective of depression beyond theories about neurotransmitters or receptor sites, and may explain the persistent signs and symptoms of depression.
关于抑郁症是否是一种身体疾病存在争议，部分原因是没有可重复、敏感和特异的生物学标志物。然而，有证据表明线粒体功能障碍和氧化应激可能与异常的大脑功能和情绪障碍（如抑郁症）有关。本文综述了一些人类和动物研究的证据，这些研究表明特定脑区的细胞内线粒体代谢功能障碍与重度抑郁症有关。这支持了慢性特定组织中线粒体功能障碍可能与抑郁症有关的假说。评估特定组织中的线粒体功能障碍可能会拓宽对抑郁症的认识，超越关于神经递质或受体部位的理论，并可能解释抑郁症持续存在的症状。
