Balas-Nakash Margie, Perichart-Perera Otilia, Benítez-Arciniega Alejandra, Tolentino-Dolores Maricruz, Mier-Cabrera Jennifer, Vadillo-Ortega Felipe
Departamento de Investigación en Nutrición, Subdirección de Investigación en Salud Pública, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, México, D.F.
Gac Med Mex. 2013 Mar-Apr;149(2):196-203.
To evaluate the differences in inflammation markers and cardiovascular risk factors in a group of school-aged children with and without excessive adiposity. To examine the relationship between adiposity, inflammation, and cardiovascular risk factors.
Cross-sectional study of 285 school children (8-12 years old). Adiposity (body mass index, BMI, total body fat, TBF, and waist circumference), inflammatory markers (C-reactive protein [CRP], interleukin 1β [IL-1β], interleukin 6 [IL-6], and tumor necrosis factor-a [TNF-α]) and cardiovascular risk factors were analyzed. Mean differences were calculated and multiple regression models were made.
Obese children had higher concentrations of CRP and IL-1β; children with abdominal obesity also had higher CRP levels. A higher BMI was associated with higher blood pressure, and higher total cholesterol, triglycerides-TAG, and insulin concentrations, and with lower HDL-cholesterol. The CRP and IL-1β concentrations correlated significantly with the three adiposity indices. The IL-6 concentrations were associated with TAG, and IL-1β with HDL-cholesterol concentration, after adjustment by BMI.
In a group of school-aged Mexican children, obesity increases cardiovascular risk and inflammation. Both IL-6 and IL-1β appear to be factors involved in lipid alterations in these children. More research is needed in order to explore the role of subclinical inflammation in the development of cardiovascular alterations that have already been described in Mexican children with obesity.
评估一组有和没有过度肥胖的学龄儿童在炎症标志物和心血管危险因素方面的差异。研究肥胖、炎症和心血管危险因素之间的关系。
对285名学龄儿童（8至12岁）进行横断面研究。分析肥胖指标（体重指数、BMI、全身脂肪、TBF和腰围）、炎症标志物（C反应蛋白[CRP]、白细胞介素1β[IL-1β]、白细胞介素6[IL-6]和肿瘤坏死因子-α[TNF-α]）以及心血管危险因素。计算均值差异并建立多元回归模型。
肥胖儿童的CRP和IL-1β浓度较高；腹部肥胖儿童的CRP水平也较高。较高的BMI与较高的血压、总胆固醇、甘油三酯-TAG和胰岛素浓度相关，且与较低的高密度脂蛋白胆固醇相关。CRP和IL-1β浓度与三个肥胖指标显著相关。经BMI调整后，IL-6浓度与TAG相关，IL-1β与高密度脂蛋白胆固醇浓度相关。
在一组墨西哥学龄儿童中，肥胖会增加心血管风险和炎症。IL-6和IL-1β似乎都是这些儿童脂质改变的相关因素。为了探究亚临床炎症在墨西哥肥胖儿童已被描述的心血管改变发展中的作用，还需要更多研究。
